Magnus Sandvik Edvardsen

Avhandlingen er tilgjengelig her! The doctoral thesis! Prøveforelesning over oppgitt emne holdes kl. 10.15, samme sted. “Acquired and hereditary bleeding disorders and therapeutic approaches. Future therapeutic perspectives with focus on the von Willebrand’s factor and factor VIII”. Prøveforelesningen vil også bli strømmet/the trail lecture will also be streamed Disputasen starter kl. 1215 og vil bli strømmet her. Opptak av disputasen vil være tilgjengelig i et døgn. The defense will be streamed here. A recording of the disputation will be available for 24 hours.

Populærvitenskapelig sammendrag av avhandlingen:

Venous thromboembolism (VTE) is a common and deadly disease which forms a major burden in society. Von Willebrand factor (VWF) is a key player in haemostasis due to its ability to capture platelets and its role as the carrier of coagulation factor (F)VIII. VWF is likely causally involved in venous thrombus formation, but the separate effects of platelet interaction and FVIII remain to be disentangled.

Using data from the Tromsø Study, we investigated the prospective association between plasma VWF and VTE, including assessments of platelet interaction and analyses of ADAMTS13, the main regulator of VWF. We found that high plasma level of VWF and low levels of ADAMTS13 were associated with increased VTE risk. Furthermore, our results indicated that platelet interaction is involved in the mechanism by which VWF promotes venous thrombus formation. Further insights into these mechanisms may provide improved strategies for VTE treatment and prevention.

Hovedveileder
Professor John Bjarne Hansen, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveileder
Professor Sigrid Kufaas Brækkan, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
Forsker Vania Maris Morelli, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet. 

Bedømmelseskomité
Professor David Lillicrap, Department of Pathology and Molecular Medicine, Queen's University (Canada) - 1. opponent.
Professor Pål Andre Holme, Institutt for indremedisinsk forskning, UiO/ OUS Rikshospitalet, Norway– 2. opponent.
Førsteamanuensis Maria Averina, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet - leder av komité.

Disputasleder: Førsteamanuensis Åsa Birna Birgisdottir, Institutt for klinisk medisin, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

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