Dominik Ausbacher

Førsteamanuensis Farmasiija instituhtta
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  • Eksteen, Jacobus Johannes; Ausbacher, Dominik; Vasskog, Terje; Rekdal, Øystein; Svendsen, John Sigurd Mjøen. Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors. ACS Omega 2020; Volum 5 (10). ISSN 2470-1343.s 4937 - 4942.s doi: 10.1021/acsomega.9b00700.

  • Paulsen, Marianne Hagensen; Ausbacher, Dominik; Bayer, Annette; Engqvist, Magnus; Hansen, Terkel; Haug, Tor; Anderssen, Trude; Andersen, Jeanette hammer; Sollid, Johanna U Ericson; Strøm, Morten B.. Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character. European Journal of Medicinal Chemistry 2019; Volum 183. ISSN 0223-5234.s 111671 - 111682.s doi: 10.1016/j.ejmech.2019.111671.

  • Paulsen, Marianne Hagensen; Karlsen, Eskil Andre; Ausbacher, Dominik; Anderssen, Trude; Bayer, Annette; Ochtrop, Philipp; Hedberg, Christian; Haug, Tor; Sollid, Johanna U Ericson; Strøm, Morten B.. An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multi-resistant bacteria. Journal of Peptide Science 2018; Volum 24 (10). ISSN 1075-2617.s 1 - 11.s doi: 10.1002/psc.3117.

  • Ausbacher, Dominik; Lorenz, Lindsey A.; Pitts, Betsey; Stewart, Philip S.; Goeres, Darla M.. Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm. Letters in Applied Microbiology 2017; Volum 66 (3). ISSN 0266-8254.s 231 - 237.s doi: 10.1111/lam.12843.

  • Eksteen, Jacobus Johannes; Ausbacher, Dominik; Simon-Santamaria, Jaione; Stiberg, Trine; Cavalcanti Jacobsen, Cristiane de Albuquerque; Wushur, Imin; Svendsen, John Sigurd Mjøen; Rekdal, Øystein. Iterative design and in vivo evaluation of an oncolytic antilymphoma peptide. Journal of Medicinal Chemistry 2016; Volum 60 (1). ISSN 0022-2623.s 146 - 156.s doi: 10.1021/acs.jmedchem.6b00839.

  • Paulsen, Marianne H.; Engqvist, Magnus; Ausbacher, Dominik; Strøm, Morten B.; Bayer, Annette. Efficient and scalable synthesis of α,α-disubstituted β-amino amides. Organic and biomolecular chemistry 2016; Volum 14 (31). ISSN 1477-0520.s 7570 - 7578.s doi: 10.1039/c6ob01219a.

  • Hanski, Leena; Ausbacher, Dominik; Tiirola, Terttu; Strøm, Morten B.; Vuorela, Pia M.. Amphipathic β2,2-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia Pneumoniae. (fulltekst) (sammendrag) PLOS ONE 2016; Volum 11 (6). ISSN 1932-6203.s doi: 10.1371/journal.pone.0157306.

  • Ausbacher, Dominik; Fallarero, Adyary; Kujala, Janni; Määttänen, Anni; Peltonen, Jouko; Strøm, Morten B.; Vuorela, Pia M.. Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives. Biofouling (Print) 2014; Volum 30 (1). ISSN 0892-7014.s 81 - 93.s doi: 10.1080/08927014.2013.847924.

  • Sivertsen, Annfrid; Tørfoss, Veronika; Isaksson, Johan; Ausbacher, Dominik; Anderssen, Trude; Brandsdal, Bjørn Olav; Havelkova, Martina; Skjørholm, Anne Elisabeth; Strøm, Morten B.. Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin. Journal of Peptide Science 2014; Volum 20 (4). ISSN 1075-2617.s 279 - 291.s doi: 10.1002/psc.2615.

  • Tørfoss, Veronika; Ausbacher, Dominik; Cavalcanti Jacobsen, Cristiane de Albuquerque; Hansen, Terkel; Brandsdal, Bjørn Olav; Havelkova, Martina; Strøm, Morten B.. Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block. Journal of Peptide Science 2012; Volum 18 (3). ISSN 1075-2617.s 170 - 176.s doi: 10.1002/psc.1434.

  • Hansen, Terkel; Ausbacher, Dominik; Zachariassen, Zack Georg; Anderssen, Trude; Havelkova, Martina; Strøm, Morten B.. Anticancer activity of small amphipathic β2,2-amino acid derivatives. European Journal of Medicinal Chemistry 2012; Volum 58. ISSN 0223-5234.s 22 - 29.s doi: 10.1016/j.ejmech.2012.09.048.

  • Tørfoss, Veronika; Isaksson, Johan; Ausbacher, Dominik; Brandsdal, Bjørn Olav; Flaten, Gøril Eide; Anderssen, Trude; Cavalcanti Jacobsen, Cristiane de Albuquerque; Havelkova, Martina; Nguyen, Leonard T.; Vogel, Hans J.; Strøm, Morten B.. Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid. Journal of Peptide Science 2012; Volum 18 (10). ISSN 1075-2617.s 609 - 619.s doi: 10.1002/psc.2441.

  • Ausbacher, Dominik; Svineng, Gunbjørg; Hansen, Terkel; Strøm, Morten B.. Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes 2012; Volum 1818 (11). ISSN 0005-2736.s 2917 - 2925.s doi: 10.1016/j.bbamem.2012.07.005.

  • Hansen, Terkel; Ausbacher, Dominik; Flaten, Gøril Eide; Havelkova, Martina; Strøm, Morten B.. Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration. Journal of Medicinal Chemistry 2011; Volum 54 (3). ISSN 0022-2623.s 858 - 868.s doi: 10.1021/jm101327d.

  • Hupfeld, Stefan; Moen, Helene; Ausbacher, Dominik; Haas, Heinrich; Brandl, Martin. Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid. Chemistry and Physics of Lipids 2010; Volum 163 (2). ISSN 0009-3084.s 141 - 147.s doi: 10.1016/j.chemphyslip.2009.10.009.

  • Hupfeld, Stefan; Ausbacher, Dominik; Brandl, Martin. Asymmetric flow field-flow fractionation of liposomes: 2. Concentration detection and adsorptive loss phenomena. Journal of Separation Science 2009; Volum 32 (20). ISSN 1615-9306.s 3555 - 3561.s doi: 10.1002/jssc.200900292.

  • Hupfeld, Stefan; Ausbacher, Dominik; Brandl, Martin. Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables. Journal of Separation Science 2009; Volum 32 (9). ISSN 1615-9306.s 1465 - 1470.s doi: 10.1002/jssc.200800626.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics. Course: Microbial lifestyles and drug discovery of antimicrobials (omtale) 2018-04-16 - 2018-05-11 2018.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics. University of Helsinki - Advanced Course on Microbial Lifestyles and Drug Discovery of Antimicrobials (prosjekt) 2017-05-02 - 2017-05-19 2017.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics. University of Helsinki - Advanced Course on Microbial Lifestyles and Drug Discovery of Antimicrobials 2016-04-26 - 2016-05-27 2016.

  • Ausbacher, Dominik; Lorenz, Lindsey A.; Goeres, Darla M.; Stewart, Philip S.; Strøm, Morten B.; Vuorela, Pia M.; Fallarero, Adyary. Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. Annual DPhG meeting 2016-10-05 - 2016-10-07 2016.

  • Hanski, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M. Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production.. Conference on Lung and Respiratory Care 2016-08-01 - 2016-08-02 2016.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides (AMPs) as templates for novel anti-infective therapeutics. University of Helsinki - Advanced Course on Microbial Lifestyles and Drug Discovery of Antimicrobials 2015-03-23 - 2015-04-24 2015.

  • Ausbacher, Dominik. β2,2-amino acid derivatives developed from antimicrobial peptides: Biological activity and mechanism of action studies. Center for Biofilm Engineering - Research Seminar 2015-04-23 - 2015-04-23 2015.

  • Ausbacher, Dominik. Antimicrobial and anticancer β2,2-amino acid derivatives: Peptide mimetics with potential for oral administration. Montana Biofilm Meeting 2015-07-13 - 2015-07-17 2015.

  • Ausbacher, Dominik; Hanski, Leena; Tiirola, Terttu; Strøm, Morten B.; Pia, Vuorela. Anti-Chlamydia pneumoniae activity of β2,2- amino acid derivatives mimicking antimicrobial peptides. Center for Drug Research Seminar 2014-09-04 - 2014-09-05 2014.

  • Fallarero, Adyary; Skogman, Malena; Moreira, Vânia; Manner, Suvi; Ausbacher, Dominik; Leino, Reko; Strøm, Morten B.; Yli-Kauhaluoma, Jari; Vuorela, Pia. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects 2013-09-09 - 2013-09-12 2013.

  • Pohjala, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M.. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research 2012-07-01 - 2012-07-06 2012.

  • Ausbacher, Dominik; Kujala, Janni; Vuorela, Pia M.; Strøm, Morten B.; Fallarero, Adyary. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides 2012-06-13 - 2012-06-15 2012.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.

  • Hansen, Terkel; Ausbacher, Dominik; Havelkova, Martina; Strøm, Morten B.. Bactericidal activity of small β-peptidomimetics. European Peptide Symposium 2010-09-05 - 2010-09-09 2010.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics. Course: Microbial lifestyles and drug discovery of antimicrobials (omtale) 2018-04-16 - 2018-05-11 2018.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics. University of Helsinki - Advanced Course on Microbial Lifestyles and Drug Discovery of Antimicrobials (prosjekt) 2017-05-02 - 2017-05-19 2017.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics. University of Helsinki - Advanced Course on Microbial Lifestyles and Drug Discovery of Antimicrobials 2016-04-26 - 2016-05-27 2016.

  • Ausbacher, Dominik; Lorenz, Lindsey A.; Goeres, Darla M.; Stewart, Philip S.; Strøm, Morten B.; Vuorela, Pia M.; Fallarero, Adyary. Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal. Annual DPhG meeting 2016-10-05 - 2016-10-07 2016.

  • Hanski, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M. Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production.. Conference on Lung and Respiratory Care 2016-08-01 - 2016-08-02 2016.

  • Ausbacher, Dominik. Exploiting innate antimicrobial defenses: Antimicrobial peptides (AMPs) as templates for novel anti-infective therapeutics. University of Helsinki - Advanced Course on Microbial Lifestyles and Drug Discovery of Antimicrobials 2015-03-23 - 2015-04-24 2015.

  • Ausbacher, Dominik. β2,2-amino acid derivatives developed from antimicrobial peptides: Biological activity and mechanism of action studies. Center for Biofilm Engineering - Research Seminar 2015-04-23 - 2015-04-23 2015.

  • Ausbacher, Dominik. Antimicrobial and anticancer β2,2-amino acid derivatives: Peptide mimetics with potential for oral administration. Montana Biofilm Meeting 2015-07-13 - 2015-07-17 2015.

  • Ausbacher, Dominik; Hanski, Leena; Tiirola, Terttu; Strøm, Morten B.; Pia, Vuorela. Anti-Chlamydia pneumoniae activity of β2,2- amino acid derivatives mimicking antimicrobial peptides. Center for Drug Research Seminar 2014-09-04 - 2014-09-05 2014.

  • Fallarero, Adyary; Skogman, Malena; Moreira, Vânia; Manner, Suvi; Ausbacher, Dominik; Leino, Reko; Strøm, Morten B.; Yli-Kauhaluoma, Jari; Vuorela, Pia. The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective. 3rd European Congress on Microbial Biofilms - Basic and Clinical Aspects 2013-09-09 - 2013-09-12 2013.

  • Pohjala, Leena; Ausbacher, Dominik; Strøm, Morten B.; Vuorela, Pia M.. Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides. 7th meeting of the European society for Chlamydia research 2012-07-01 - 2012-07-06 2012.

  • Ausbacher, Dominik; Kujala, Janni; Vuorela, Pia M.; Strøm, Morten B.; Fallarero, Adyary. Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives. 3rd International Symposium on Antimicrobial Peptides 2012-06-13 - 2012-06-15 2012.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics. Biopolymers 2011; Volum 96 (4). ISSN 0006-3525.s 456 - 457.

  • Ausbacher, Dominik; Hansen, Terkel; Svineng, Gunbjørg; Strøm, Morten B.. Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics. American Peptide Symposium 2011-06-25 - 2011-06-30 2011.

  • Hansen, Terkel; Ausbacher, Dominik; Havelkova, Martina; Strøm, Morten B.. Bactericidal activity of small β-peptidomimetics. European Peptide Symposium 2010-09-05 - 2010-09-09 2010.

  • Member of research group

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