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Photo: Marit Helgerud

John Sigurd Mjøen Svendsen



  • Anne Sofie Laulund, Franziska Angelika Schwartz, Lars Christophersen, Niels Høiby, John Sigurd Mjøen Svendsen, Wenche Gunvor Berg Stensen et al.:
    Lactoferricin-inspired peptide AMC-109 augments the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic murine wounds
    Journal of Global Antimicrobial Resistance 2022 ARKIV / DOI
  • Bangfu Zhu, Tom Parsons, Wenche Gunvor Berg Stensen, John Sigurd Mjøen Svendsen, Anders Fugelli, James W.L. Hodge :
    DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes
    Frontiers in Pharmacology 2022 ARKIV / DOI
  • Joakim Håkansson, Jorunn Pauline Cavanagh, Wenche Gunvor Berg Stensen, Bjarte Mortensen, John Sigurd Mjøen Svendsen, Johan Svenson :
    In vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound dressings and gels
    Journal of antibiotics (Tokyo. 1968) 2021 DOI
  • Wenche Stensen, Ulli Rothweiler, Richard Alan Engh, Melissa R. Stasko, Ilya Bederman, Alberto C. S. Costa et al.:
    Novel DYRK1A Inhibitor Rescues Learning and Memory Deficits in a Mouse Model of Down Syndrome
    Pharmaceuticals 2021 ARKIV / FULLTEKST / DOI
  • Eskil André Karlsen, Wenche Stensen, Eric Juskewitz, Johan Svenson, Mattias Berglin, John Sigurd Mjøen Svendsen :
    Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis
    Antibiotics 2021 FULLTEKST / ARKIV / DOI
  • Worku Dinku, Johan Isaksson, Fredrik G. Rylandsholm, Petr Bouř, Eva Brichtova, Sang Un Choi et al.:
    Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
    Applied Biological Chemistry 2020 ARKIV / DOI
  • Jacobus Johannes Eksteen, Dominik Ausbacher, Terje Vasskog, Øystein Rekdal, John Sigurd Mjøen Svendsen :
    Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors
    ACS Omega 2020 ARKIV / DOI
  • John Sigurd Mjøen Svendsen, Thomas M Grant, David Rennison, Margaret A. Brimble, Johan Svenson :
    Very Short and Stable Lactoferricin-Derived Antimicrobial Peptides: Design Principles and Potential Uses
    Accounts of Chemical Research 2019 DOI
  • Balmukund Thakkar, John Sigurd Mjøen Svendsen, Richard Alan Engh :
    Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization
    Molecules 25. Sep 2018 SAMMENDRAG / DATA / FULLTEKST / ARKIV / DOI
  • Balmukund Thakkar, Marte Albrigtsen, John Sigurd Mjøen Svendsen, Jeanette hammer Andersen, Richard Alan Engh :
    Biofocussed chemoprospecting: An efficient approach for drug discovery
    Chemical Biology and Drug Design (CB&DD) 13. Jun 2017 FULLTEKST / SAMMENDRAG / DOI
  • Balmukund Thakkar, John Sigurd Mjøen Svendsen, Richard Alan Engh :
    Cis/Trans Isomerization in Secondary Amides: Reaction Paths, Nitrogen Inversion and Relevance to Peptidic Systems
    Journal of Physical Chemistry A 15. Aug 2017 FULLTEKST / DOI
  • Bengt Erik Haug, Ketil Andre Camilio, liv tone Eliassen, Wenche Stensen, John Sigurd Mjøen Svendsen, Kristel Berg et al.:
    Discovery of a 9-mer cationic peptide (LTX-315) as a potential first in class oncolytic peptide
    Journal of Medicinal Chemistry 2016 DOI
  • Wenche Stensen, Rob Turner, Marc Brown, Nahid Kondori, John Sigurd Mjøen Svendsen, Johan Svenson :
    Short Cationic Antimicrobial Peptides Display Superior Antifungal Activities toward Candidiasis and Onychomycosis in Comparison with Terbinafine and Amorolfine
    Molecular Pharmaceutics 2016 DOI
  • Ulli Rothweiler, Wenche Stensen, Bjørn Olav Brandsdal, Johan Isaksson, Frederick Alan Leeson, Richard Alan Engh et al.:
    Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules
    Journal of Medicinal Chemistry 2016 DOI
  • Jacobus Johannes Eksteen, Dominik Ausbacher, Jaione Simon-Santamaria, Trine Stiberg, Cristiane de Albuquerque Cavalcanti Jacobsen, Imin Wushur et al.:
    Iterative design and in vivo evaluation of an oncolytic antilymphoma peptide
    Journal of Medicinal Chemistry 2016 DOI
  • Ulli Rothweiler, Jonas Eriksson, Wenche Stensen, Frederick Alan Leeson, Richard Alan Engh, John Sigurd Svendsen :
    Luciferin and derivatives as a DYRK selective scaffold for the design of protein kinase inhibitors
    European Journal of Medicinal Chemistry 2015 DOI
  • Annfrid Sivertsen, Johan Isaksson, Hanna-Kirsti S. Leiros, Johan Svenson, John Sigurd Svendsen, Bjørn Olav Brandsdal :
    Synthetic cationic antimicrobial peptides bind with their hydrophobic parts to drug site II of human serum albumin
    BMC Structural Biology 2014 ARKIV / DOI
  • Olga Vladimirovna Gozhina, John Sigurd Svendsen, Tore Lejon :
    Synthesis and antimicrobial activity of α-aminoboronic-containing peptidomimetics
    Journal of Peptide Science 2014 DOI
  • Rozenn Trepos, Gunnar Cervin, Claire Hellio, Henrik Pavia Henrik, Wenche Stensen, Klara Stensvåg et al.:
    Antifouling compounds from the sub-arctic ascidian synoicum pulmonaria: Synoxazolidinones A and C, pulmonarins A and B, and synthetic analogues
    Journal of natural products 2014 DOI
  • Alexey Sergeevich Gorovoy, Olga Vladimirovna Gozhina, John Sigurd Svendsen, Anna A. Domorad, Victor V. Tetz, George V. Tetz et al.:
    Boron containing peptidomimetics – a novel class of selective anti-tubercular drugs
    Chemical Biology and Drug Design (CB&DD) 2013 DOI
  • Xiaojun Li, Kathrin Helen Hopmann, Jana Hudecova, Johan Isaksson, Jana Novotná, Wenche Stensen et al.:
    Determination of Absolute Configuration and Conformation of a Cyclic Dipeptide by NMR and Chiral Spectroscopic Methods
    Journal of Physical Chemistry A 2013 DOI
  • Taye B. Demissie, Michal Repisky, Stanislav Komorovsky, Johan Isaksson, John Sigurd Svendsen, H Dodziuk :
    Four-component relativistic chemical shift calculations of halogenated organic compounds
    Journal of Physical Organic Chemistry 2013 DOI
  • Alexey Sergeevich Gorovoy, Olga Vladimirovna Gozhina, John Sigurd Svendsen, George V. Tetz, Anna A. Domorad, Victor V. Tetz et al.:
    Syntheses and anti-tubercular activity of β-substituted and α,β-disubstituted peptidyl β-aminoboronates and boronic acids
    Journal of Peptide Science 2013 DOI
  • Annfrid Sivertsen, Bjørn Olav Brandsdal, John Sigurd Svendsen, Jeanette hammer Andersen, Johan Svenson :
    Short cationic antimicrobial peptides bind to human alpha-1 acid glycoprotein with no implications for the in vitro bioactivity
    Journal of Molecular Recognition 2013 DOI
  • Kathrin Helen Hopmann, Jaroslav Šebestík, Jana Novotná, Wenche Stensen, Marie Urbanová, Johan Svenson et al.:
    Determining the Absolute Configuration of Two Marine Compounds Using Vibrational Chiroptical Spectroscopy
    Journal of Organic Chemistry 2012 DOI
  • Kine Østnes Hanssen, Bruno Schuler, Antony J. Williams, Taye B. Demissie, Espen Hansen, Jeanette hammer Andersen et al.:
    A Combined Atomic Force Microscopy and Computational Approach for the Structural Elucidation of Breitfussin A and B: Highly Modified Halogenated Dipeptides from Thuiaria breitfussi
    Angewandte Chemie International Edition 2012 DOI
  • Rasmus Tørnes Karstad, Geir Villy Isaksen, Evelien Wynendaele, Yngve Guttormsen, Bart De Spiegeleer, Bjørn Olav Brandsdal et al.:
    Targeting the S1 and S3 Subsite of Trypsin with Unnatural Cationic Amino Acids Generates Antimicrobial Peptides with Potential for Oral Administration
    Journal of Medicinal Chemistry 2012 DOI
  • Xiaojun Li, Kathrin Helen Hopmann, Jana Hudecova, Wenche Stensen, Jana Novotná, Marie Urbanová et al.:
    Absolute Configuration of a Cyclic Dipeptide Reflected in Vibrational Optical Activity: Ab Initio and Experimental Investigation
    Journal of Physical Chemistry A 2012 DOI
  • Johan Isaksson, Bjørn Olav Brandsdal, Stig Olov Magnus Engqvist, Gøril Eide Flaten, John Sigurd Svendsen, Wenche Stensen :
    A Synthetic Antimicrobial Peptidomimetic (LTX 109): Stereochemical Impact on Membrane Disruption
    Journal of Medicinal Chemistry 2011 DOI
  • Derk Avenarius, John Sigurd Svendsen, Dag Malm :
    Proton nuclear magnetic resonance spectroscopic detection of oligomannosidic n glycans in alpha-mannosidosis: a method of monitoring treatment
    The Journal of Inherited Metabolic Disease (JIMD) 2011 DOI
  • Gøril Eide Flaten, Gabor Kottra, Wenche Stensen, Geir Villy Isaksen, Rasmus Tørnes Karstad, John Sigurd Svendsen et al.:
    In Vitro Characterization of Human Peptide Transporter hPEPT1 Interactions and Passive Permeation Studies of Short Cationic Antimicrobial Peptides
    Journal of Medicinal Chemistry 2011 DOI
  • Johan Svenson, V Vergote, Rasmus Tørnes Karstad, C Burvenich, John Sigurd Svendsen, B De Spiegeleer :
    Metabolic Fate of Lactoferricin-Based Antimicrobial Peptides: Effect of Truncation and Incorporation of Amino Acid Analogs on the In Vitro Metabolic Stability
    Journal of Pharmacology and Experimental Therapeutics 2010 DOI
  • Rasmus Tørnes Karstad, Geir Isaksen, Bjørn Olav Brandsdal, John Sigurd Svendsen, Johan Svenson :
    Unnatural Amino Acid Side Chains as S1, S1 ', and S2 ' Probes Yield Cationic Antimicrobial Peptides with Stability toward Chymotryptic Degradation
    Journal of Medicinal Chemistry 2010 DOI
  • Kristina Flemming, Claus Klingenberg, Jorunn Pauline Cavanagh, Merethe vibeke Sletteng, Wenche Stensen, John Sigurd Svendsen et al.:
    High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms
    Journal of Antimicrobial Chemotherapy 2009 DOI
  • Johan Svenson, Rasmus Tørnes Karstad, Gøril Eide Flaten, Bjørn Olav Brandsdal, Martin Brandl, John Sigurd Svendsen :
    Altered Activity and Physicochemical Properties of Short Cationic Antimicrobial Peptides by Incorporation of Arginine Analogues
    Molecular Pharmaceutics 2009 DOI
  • Johan Karl Svenson, Wenche Stensen, Bjørn Olav Brandsdal, Bengt Erik Haug, Johnny Monrad, John Sigurd Svendsen :
    Antimicrobial Peptides with Stability toward Tryptic Degradation
    Biochemistry 2008 DOI
  • Bengt Erik Haug, Wenche Stensen, manar Kalaaji, Øystein Rekdal, John Sigurd Svendsen :
    Synthetic antimicrobial peptidomimetics with therapeutic potential
    Journal of Medicinal Chemistry 2008 DOI
  • John Sigurd Mjøen Svendsen :
    Hva betyr antibiotikakrisen for kreftpasienter
    2018
  • John Sigurd Mjøen Svendsen :
    Paneldebatt: Antibiotikaresistens og kreft
    2018
  • John Sigurd Mjøen Svendsen :
    Panel: Are new antibiotics the solution to the AMR threat?
    2018
  • Finn-Eirik Johansen, Trygve Brautaset, Marie Hjelmseth Aune, Alexandra Patriksson, Liv Eggset Falkenberg, Rune Kleppe et al.:
    Centre for Digital Life Norway - Annual report 2017
    2018 ARKIV
  • Inger Greve Alsos, Torbjørn Ekrem, John Sigurd Svendsen :
    Lager digitalt oppslagsverk over alt liv på jorda
    13. Mar 2014 FULLTEKST
  • Inger Greve Alsos, Torbjørn Ekrem, John Sigurd Svendsen :
    DNA fra planter og dyr kan gi kunnskap om sykdommer
    13. Mar 2014 FULLTEKST
  • Inger Greve Alsos, Torbjørn Ekrem, John Sigurd Svendsen :
    - Kan bidra til utviklingen av nye medisiner
    13. Mar 2014 FULLTEKST
  • Claire Hellio, Henrik Pavia, Tor Haug, Wenche Stensen, Klara Stensvåg, John Sigurd Svendsen et al.:
    Antifouling compounds from the sub-Arctic ascidian Synoicum pulmonaria
    2014
  • Kine Ø. Hanssen, Bruno Schuler, Antony J. Williams, Taye B. Demissie, Espen Hansen, Jeanette hammer Andersen et al.:
    Introducing Atomic Force Microscopy in Structure Elucidation
    2013
  • Balmukund Thakkar, John Sigurd Mjøen Svendsen, Richard Alan Engh :
    Design and Synthesis of diverse Piperazine-2,5-diones and their uncyclized analogues as potential kinase inhibitors
    2013
  • Geir Villy Isaksen, Johan Isaksson, John Sigurd Svendsen, Bjørn Olav Brandsdal :
    Structural studies of small cationic antimicrobial peptides by NMR and computer simulations have facilitated a refined pharmacophore model able to predict activity versus Staphylococcus aureus
    2011
  • Geir Villy Isaksen, Rasmus Tørnes Karstad, Johan Mattias Isaksson, Johan Svenson, John Sigurd Svendsen, Bjørn Olav Brandsdal :
    Structure of short cationic antimicrobial peptides and their interactions with membranes as revealed by MD simulations
    2010
  • Johan Isaksson, Gøril Eide Flaten, Bjørn Olav Brandsdal, John Sigurd Svendsen :
    Studies of Small Synthetic Anti-microbial Peptides by NMR and Molecular Modeling
    2010

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