Christopher Frøhlich
Christopher Frøhlich,
H. Adrian Bunzel,
Karol Buda,
Adrian J. Mulholland,
Marc W. van der Kamp,
Pål Jarle Johnsen
et al.:
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Øyvind Myrvoll Lorentzen,
Anne Sofie B. Haukefer,
Pål Jarle Johnsen,
Christopher Frøhlich
:
The Biofilm Lifestyle Shapes the Evolution of β-Lactamases
Alexandra Kondratieva,
Katarzyna Palica,
Christopher Frøhlich,
Rebekka Rolfsnes Hovd,
Hanna-Kirsti S. Leiros,
Máté Erdélyi
et al.:
Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose
Yuwen Jia,
Barbara Schroeder,
Yvonne Pfeifer,
Christopher Frøhlich,
Lihua Deng,
Christoph Arkona
et al.:
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems
Journal of Medicinal Chemistry 2023 DOI
Christopher Frøhlich,
John Z Chen,
Sevan Gholipour,
Ayse N Erdogan,
Nobuhiko Tokuriki
:
Evolution of β-lactamases and enzyme promiscuity
Christopher Frøhlich,
João Alves Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte Aarmo Lund,
Marc W. van der Kamp
et al.:
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Ørjan Samuelsen,
Ove Alexander Høgmoen Åstrand,
Christopher Frøhlich,
Adam Heikal,
Susann Skagseth,
Trine Josefine Olsen Carlsen
et al.:
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
Christopher Frøhlich,
Vidar Sørum,
Sandra Huber,
Ørjan Samuelsen,
Fanny Berglund,
Erik Kristiansson
et al.:
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
Zeeshan Muhammad,
Susann Skagseth,
Marc Boomgaren,
Sundus Akhter,
Christopher Frøhlich,
Aya Ismael
et al.:
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim,
Zineb Bousfiha,
Christopher Fröhlich
et al.:
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
Geir Kildahl-Andersen,
Christian Schnaars,
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim
et al.:
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors
MedChemComm 2019 DOI
Christopher Frøhlich,
Vidar Sørum,
Ane Molden Thomassen,
Pål Jarle Johnsen,
Hanna-Kirsti S. Leiros,
Ørjan Samuelsen
:
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
Christian Schnaars,
Geir kildahl-Andersen,
Anthony Prandina,
Roya Popal,
Sylvie Radix,
Marc Le Borgne
et al.:
Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors
ACS Infectious Diseases 2018 DOI
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Evolution of β-lactamase-mediated cefiderocol resistance
Christopher Frøhlich
:
Naturens egen magi: Når 2+2 blir 12
Christopher Frøhlich
:
Divergent genetic evolution employs the same molecular mechanisms
2024
Christopher Frøhlich,
H. Adrian Bunzel,
Karol Buda,
Adrian J. Mulholland,
Marc W. van der Kamp,
Pål Jarle Johnsen
et al.:
Correction to: Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase (Nature Catalysis, (2024), 10.1038/s41929-024-01117-4)
Nature Catalysis 2024 DOI
Øyvind Myrvoll Lorentzen,
Christopher Fröhlich,
Anne Sofie Haukefer,
Sören Abel,
Pål Jarle Johnsen
:
Evolution of Vibrio cholerae biofilms
2023
Rebekka Rolfsnes Hovd,
Pål Rongved,
Ragnar Hovland,
Åsmund Kaupang,
Christopher Frøhlich,
Sandra Huber
et al.:
Investigating the Mechanism of Action of a New Novel Dual β-Lactamase Inhibitor
2023
Christopher Frøhlich,
Adrian Bunzel,
Karol Buda,
Pål Jarle Johnsen,
Nobuhiko Tokuriki
:
Divergent genetic evolution employs the same molecular mechanisms
2023
Rebekka Rolfsnes Hovd,
Pål Rongved,
Ragnar Hovland,
Åsmund Kaupang,
Christopher Frøhlich,
Sandra Huber
et al.:
Investigating the Mechanism of Action of a Novel Dual β-Lactamase Inhibitor
2023
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Ørjan Samuelsen
:
Evolution of ß-lactamase mediated cefiderocol resistance
2022
Christopher Frøhlich,
Adrian H. Bunzel,
Marc W. Van Der Kamp,
Adrian J. Mulholland,
Hanna-Kirsti Schrøder Leiros,
Pål Jarle Johnsen
et al.:
Positive epistasis drives the molecular evolution of the carbapenemase OXA-48
2022
Christopher Frøhlich,
Hanna-Kirsti S. Leiros
:
Vi må kanskje ta antibiotika hyppigere
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Charlotte Miton,
Nobuhiko Tokuriki
:
Ceftazidime drives the evolution of the carbapenemase OXA-48
2020
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
2019
Christopher Frøhlich,
Pål Jarle Johnsen,
Hanna-Kirsti Schrøder Leiros,
Ørjan Samuelsen
:
Evolution of OXA-48 under sub-MIC conditions
2019
Christopher Frøhlich,
Vidar Sørum,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
2018
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