Christopher Frøhlich
Daniel Salamonsen,
Karol Buda,
Daojiong Wang,
Kinga Virág Gulyás,
Marc W. van der Kamp,
Christopher Frøhlich
:
Mechanistic Origins and Evolutionary Erosion of Collateral Sensitivity in a β-lactamase
Morito Sakuma,
Karol Buda,
H. Adrian Bunzel,
Christopher Frøhlich,
Nobuhiko Tokuriki
:
Functional sub-states link conformational landscapes and protein evolution
Øyvind Myrvoll Lorentzen,
Sören Abel,
Pål Jarle Johnsen,
Christopher Frøhlich
:
Biofilm selection constitutively activates c-di-GMP synthesis by the bifunctional enzyme MbaA
Rebekka Rolfsnes Hovd,
Åsmund Kaupang,
Pål Rongved,
Geir Kildahl-Andersen,
Knut Tormodssønn Hylland,
Ragnar Hovland
et al.:
APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers
Øyvind Myrvoll Lorentzen,
Anne Sofie B. Haukefer,
Pål Jarle Johnsen,
Christopher Frøhlich
:
The Biofilm Lifestyle Shapes the Evolution of β-Lactamases
Christopher Frøhlich,
H. Adrian Bunzel,
Karol Buda,
Adrian J. Mulholland,
Marc W. van der Kamp,
Pål Jarle Johnsen
et al.:
Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase
Alexandra Kondratieva,
Katarzyna Palica,
Christopher Frøhlich,
Rebekka Rolfsnes Hovd,
Hanna-Kirsti S. Leiros,
Máté Erdélyi
et al.:
Fluorinated captopril analogues inhibit metallo-β-lactamases and facilitate structure determination of NDM-1 binding pose
Yuwen Jia,
Barbara Schroeder,
Yvonne Pfeifer,
Christopher Frøhlich,
Lihua Deng,
Christoph Arkona
et al.:
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems
Christopher Frøhlich,
João Alves Gama,
Klaus Harms,
Viivi H. A. Hirvonen,
Bjarte Aarmo Lund,
Marc W. van der Kamp
et al.:
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Christopher Frøhlich,
John Z Chen,
Sevan Gholipour,
Ayse N Erdogan,
Nobuhiko Tokuriki
:
Evolution of β-lactamases and enzyme promiscuity
Ørjan Samuelsen,
Ove Alexander Høgmoen Åstrand,
Christopher Frøhlich,
Adam Heikal,
Susann Skagseth,
Trine Josefine Olsen Carlsen
et al.:
ZN148 Is a Modular Synthetic Metallo-beta-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo
Christopher Frøhlich,
Vidar Sørum,
Sandra Huber,
Ørjan Samuelsen,
Fanny Berglund,
Erik Kristiansson
et al.:
Structural and biochemical characterization of the environmental MBLs MYO-1, ECV-1 and SHD-1
Zeeshan Muhammad,
Susann Skagseth,
Marc Boomgaren,
Sundus Akhter,
Christopher Frøhlich,
Aya Ismael
et al.:
Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim,
Zineb Bousfiha,
Christopher Fröhlich
et al.:
Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors
Geir Kildahl-Andersen,
Christian Schnaars,
Anthony Prandina,
Sylvie Radix,
Marc Le Borgne,
Lars Petter Jordheim
et al.:
Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors
Christopher Frøhlich,
Vidar Sørum,
Ane Molden Thomassen,
Pål Jarle Johnsen,
Hanna-Kirsti S. Leiros,
Ørjan Samuelsen
:
OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs
Christian Schnaars,
Geir kildahl-Andersen,
Anthony Prandina,
Roya Popal,
Sylvie Radix,
Marc Le Borgne
et al.:
Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Evolution of β-lactamase-mediated cefiderocol resistance
Daniel Salamonsen,
Christopher Frøhlich
:
β-lactamases: From trade-offs and adaptability to inhibitor design. The roles of collateral sensitivity, epistasis, and conformational dynamics in resistance evolution
UiT Norges arktiske universitet 16. Oct 2026 ARKIV
Øyvind Myrvoll Lorentzen,
Sören Abel,
Pål Jarle Johnsen,
Christopher Frøhlich
:
Biofilm selection constitutively activates c-di-GMP synthesis by the bifunctional enzyme MbaA
26. Nov 2025 ARKIV
Christopher Frøhlich,
H. Adrian Bunzel,
Karol Buda,
Adrian J. Mulholland,
Marc W. van der Kamp,
Pål Jarle Johnsen
et al.:
Correction to: Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase (Nature Catalysis, (2024), 10.1038/s41929-024-01117-4)
Christopher Frøhlich
:
Divergent genetic evolution employs the same molecular mechanisms
2024 ARKIV
Christopher Frøhlich,
Adrian Bunzel,
Karol Buda,
Pål Jarle Johnsen,
Nobuhiko Tokuriki
:
Divergent genetic evolution employs the same molecular mechanisms
2023 ARKIV
Rebekka Rolfsnes Hovd,
Pål Rongved,
Ragnar Hovland,
Åsmund Kaupang,
Christopher Frøhlich,
Sandra Huber
et al.:
Investigating the Mechanism of Action of a Novel Dual β-Lactamase Inhibitor
2023 ARKIV
Rebekka Rolfsnes Hovd,
Pål Rongved,
Ragnar Hovland,
Åsmund Kaupang,
Christopher Frøhlich,
Sandra Huber
et al.:
Investigating the Mechanism of Action of a New Novel Dual β-Lactamase Inhibitor
2023 ARKIV
Øyvind Myrvoll Lorentzen,
Christopher Fröhlich,
Anne Sofie Haukefer,
Sören Abel,
Pål Jarle Johnsen
:
Evolution of Vibrio cholerae biofilms
2023 ARKIV
Christopher Frøhlich,
Vidar Sørum,
Nobuhiko Tokuriki,
Ørjan Samuelsen
:
Evolution of ß-lactamase mediated cefiderocol resistance
2022 ARKIV
Christopher Frøhlich,
Adrian H. Bunzel,
Marc W. Van Der Kamp,
Adrian J. Mulholland,
Hanna-Kirsti Schrøder Leiros,
Pål Jarle Johnsen
et al.:
Positive epistasis drives the molecular evolution of the carbapenemase OXA-48
2022 ARKIV
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Charlotte Miton,
Nobuhiko Tokuriki
:
Ceftazidime drives the evolution of the carbapenemase OXA-48
2020 ARKIV
Christopher Frøhlich,
Pål Jarle Johnsen,
Hanna-Kirsti Schrøder Leiros,
Ørjan Samuelsen
:
Evolution of OXA-48 under sub-MIC conditions
2019 ARKIV
Christopher Frøhlich,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Sub-inhibitory concentrations of ceftazidime drive evolution of the OXA-48 carbapenemase
2019 ARKIV
Christopher Frøhlich,
Vidar Sørum,
Hanna-Kirsti S. Leiros,
Pål Jarle Johnsen,
Ørjan Samuelsen
:
Development of OXA-48 mediated ceftazidme-avibactam resistance is associated with an evolutionary trade-off
2018 ARKIV
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