Disputas - Master of science in Pharmacy Laura Victoria Schulte-Werning

Avhandlingen er tilgjengelig her! / The doctoral thesis is available here!

Disputasen strømmes og et opptak vil være tilgjengelig i et døgn.
The defense will be streamed, and a recording of the disputation will be available for 24 hours.

Prøveforelesning over oppgitt emne starter kl. 10.15 / The trial lecture starts at 10.15
Tittel/Title:  "Incorporating Nanotechnology into Advanced Wound Healing Therapies.”
Prøveforelesningen strømmes her / The trial lecture will be streamed here.

Disputasen starter kl. 12.15 / The defense starts at 12.15
Disputasen strømmes her / The defense will be streamed here


Populærvitenskapelig sammendrag av avhandlingen/ Summary of the thesis:

Non-healing wounds, chronic wounds, are at risk of infection and challenging to treat, wherefore novel wound dressings are needed.
To improve treatment options, we aimed at the development of a novel wound dressing that works as a tailored transport system of an incorporated antibiotic (chloramphenicol) and is composed of natural substances to use nature to aid the healing process.
We chose beta-glucan from yeast, chitosan from shrimps, and pectin from citrus peels, which have antimicrobial, wound healing and high swelling abilities, respectively. For a tailored antibiotic transport, we added chloramphenicol in small fatty vesicles, liposomes.
Using electrospinning, a technique that fabricates dressings with a unique nanosized fibrous structure (nanofibers), we manufactured dressings with the chosen ingredients in various complexities.
The nanofibers had a high ability to take up simulated wound fluid and maintained the activity of chloramphenicol, showing potential as wound dressings.

Veiledere/ Supervisors:
Hovedveileder/Main supervisor:
 Førsteamanuensis Ann Mari Holsæter, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Biveiledere/supervisors:
Professor Nataša Škalko-Basnet, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.
CSO Rolf Engstad, Biotec BetaGlucans AS.
Professor Mona Johannessen, Institutt for medisinsk biologi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.

Bedømmelseskomité/Defensecomitee:

Professor Romána Zelkó, Semmelweis University – 1. opponent.
Ph.d.  Cătălina Bogdan, Iuliu Hațieganu University of Medicine and Pharmacy – 2. opponent.
Førsteamanuensis Kristian Svendsen, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet – leder av komité.

Disputasleder/ Leader of defense: 
Førsteamanuensis Kjell H. Halvorsen, Institutt for farmasi, Det helsevitenskapelige fakultet, UiT Norges arktiske universitet.