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  3. Dominik Ausbacher
Bilde av Ausbacher, Dominik
Bilde av Ausbacher, Dominik
Farmasiija instituhtta dominik.ausbacher@uit.no +4777646657 Tromsø

Dominik Ausbacher

  • Susannah von Hofsten, Manuel K Langer, Katja Korelin, Synnøve Norvoll Magnussen, Dominik Ausbacher, Trude Anderssen et al.:
    Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines
    Frontiers in Pharmacology 30. Mar 2023 ARKIV / DOI
  • Dominik Ausbacher, Lindsey A. Miller, Darla M. Goeres, Philip S. Stewart, Morten Bøhmer Strøm, Adyary Fallarero :
    α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
    Biofilm 2023 ARKIV / DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer et al.:
    The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
    Scientific Reports 2022 ARKIV / DOI
  • Marianne Hagensen Paulsen, Magnus Engqvist, Dominik Ausbacher, Trude Anderssen, Manuel K- Langer, Tor Haug et al.:
    Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates
    Journal of Medicinal Chemistry 2021 ARKIV / DOI
  • Jacobus Johannes Eksteen, Dominik Ausbacher, Terje Vasskog, Øystein Rekdal, John Sigurd Mjøen Svendsen :
    Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors
    ACS Omega 2020 ARKIV / DOI
  • Marianne Hagensen Paulsen, Dominik Ausbacher, Annette Bayer, Magnus Engqvist, Terkel Hansen, Tor Haug et al.:
    Antimicrobial activity of amphipathic α,α-disubstituted β-amino amide derivatives against ESBL–CARBA producing multi-resistant bacteria; effect of halogenation, lipophilicity and cationic character
    European Journal of Medicinal Chemistry 2019 ARKIV / DOI
  • Marianne Hagensen Paulsen, Eskil Andre Karlsen, Dominik Ausbacher, Trude Anderssen, Annette Bayer, Philipp Ochtrop et al.:
    An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multi-resistant bacteria
    Journal of Peptide Science 2018 DOI
  • Dominik Ausbacher, Lindsey A. Lorenz, Betsey Pitts, Philip S. Stewart, Darla M. Goeres :
    Paired methods to measure biofilm killing and removal: a case study with Penicillin G treatment of Staphylococcus aureus biofilm
    Letters in Applied Microbiology 2017 ARKIV / DOI
  • Jacobus Johannes Eksteen, Dominik Ausbacher, Jaione Simon-Santamaria, Trine Stiberg, Cristiane de Albuquerque Cavalcanti Jacobsen, Imin Wushur et al.:
    Iterative design and in vivo evaluation of an oncolytic antilymphoma peptide
    Journal of Medicinal Chemistry 2016 DOI
  • Leena Hanski, Dominik Ausbacher, Terttu Tiirola, Morten B. Strøm, Pia M. Vuorela :
    Amphipathic β2,2-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia Pneumoniae
    PLOS ONE 09. Jun 2016 FULLTEKST / SAMMENDRAG / ARKIV / DOI
  • Marianne H. Paulsen, Magnus Engqvist, Dominik Ausbacher, Morten B. Strøm, Annette Bayer :
    Efficient and scalable synthesis of α,α-disubstituted β-amino amides
    Organic and biomolecular chemistry 2016 ARKIV / DOI
  • Annfrid Sivertsen, Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Trude Anderssen, Bjørn Olav Brandsdal et al.:
    Anticancer potency of small linear and cyclic tetrapeptides and pharmacokinetic investigations of peptide binding to human serum albumin
    Journal of Peptide Science 2014 DOI
  • Dominik Ausbacher, Adyary Fallarero, Janni Kujala, Anni Määttänen, Jouko Peltonen, Morten B. Strøm et al.:
    Staphylococcus aureus biofilm susceptibility to small and potent β2,2-amino acid derivatives
    Biofouling (Print) 2014 DOI
  • Veronika Tørfoss, Dominik Ausbacher, Cristiane de Albuquerque Cavalcanti Jacobsen, Terkel Hansen, Bjørn Olav Brandsdal, Martina Havelkova et al.:
    Synthesis of anticancer heptapeptides containing a unique lipophilic β2,2-amino acid building block
    Journal of Peptide Science 2012 DOI
  • Terkel Hansen, Dominik Ausbacher, Zack Georg Zachariassen, Trude Anderssen, Martina Havelkova, Morten B. Strøm :
    Anticancer activity of small amphipathic β2,2-amino acid derivatives
    European Journal of Medicinal Chemistry 2012 DOI
  • Veronika Tørfoss, Johan Isaksson, Dominik Ausbacher, Bjørn Olav Brandsdal, Gøril Eide Flaten, Trude Anderssen et al.:
    Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic b2,2-amino acid
    Journal of Peptide Science 2012 DOI
  • Dominik Ausbacher, Gunbjørg Svineng, Terkel Hansen, Morten B. Strøm :
    Anticancer mechanisms of action of two small amphipathic beta(2,2)-amino acid derivatives derived from antimicrobial peptides
    Biochimica et Biophysica Acta - Biomembranes 19. Jul 2012 DOI
  • Terkel Hansen, Dominik Ausbacher, Gøril Eide Flaten, Martina Havelkova, Morten B. Strøm :
    Synthesis of Cationic Antimicrobial beta(2,2)-Amino Acid Derivatives with Potential for Oral Administration
    Journal of Medicinal Chemistry 2011 DOI
  • Stefan Hupfeld, Helene Moen, Dominik Ausbacher, Heinrich Haas, Martin Brandl :
    Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid
    Chemistry and Physics of Lipids 2010 DOI
  • Stefan Hupfeld, Dominik Ausbacher, Martin Brandl :
    Asymmetric flow field-flow fractionation of liposomes: 2. Concentration detection and adsorptive loss phenomena
    Journal of Separation Science 2009 DOI
  • Stefan Hupfeld, Dominik Ausbacher, Martin Brandl :
    Asymmetric flow field-flow fractionation of liposomes: optimization of fractionation variables
    Journal of Separation Science 2009 DOI
  • Susannah von Hofsten, Marianne Hagensen Paulsen, Manuel K Langer, Synnøve Norvoll Magnussen, Dominik Ausbacher, Annette Bayer et al.:
    A Compound Inspired by Arctic Marine Animals Kills Cancer Cells in vitro and in vivo
    2022
  • Susannah von Hofsten, Synnøve Norvoll Magnussen, Dominik Ausbacher, Marianne Hagensen Paulsen, Annette Bayer, Morten B. Strøm et al.:
    The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death
    2020 ARKIV
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics
    2018 OMTALE
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics
    2017 PROSJEKT
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides and peptide antibiotics as templates for novel anti-infective therapeutics
    2016
  • Leena Hanski, Dominik Ausbacher, Morten B. Strøm, Pia M Vuorela :
    Impact of β2,2-amino acid derivatives, a novel class of Chlamydia pneumoniae inhibitors, on bronchial epithelium VEGF production.
    2016
  • Dominik Ausbacher, Lindsey A. Lorenz, Darla M. Goeres, Philip S. Stewart, Morten B. Strøm, Pia M. Vuorela et al.:
    Antimicrobial β2,2-amino acid derivatives eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
    2016
  • Dominik Ausbacher :
    Exploiting innate antimicrobial defenses: Antimicrobial peptides (AMPs) as templates for novel anti-infective therapeutics
    2015
  • Dominik Ausbacher :
    Antimicrobial and anticancer β2,2-amino acid derivatives: Peptide mimetics with potential for oral administration
    2015
  • Dominik Ausbacher :
    β2,2-amino acid derivatives developed from antimicrobial peptides: Biological activity and mechanism of action studies
    2015
  • Dominik Ausbacher, Leena Hanski, Terttu Tiirola, Morten B. Strøm, Vuorela Pia :
    Anti-Chlamydia pneumoniae activity of β2,2- amino acid derivatives mimicking antimicrobial peptides
    2014
  • Adyary Fallarero, Malena Skogman, Vânia Moreira, Suvi Manner, Dominik Ausbacher, Reko Leino et al.:
    The challenges of discovering new anti-biofilm probes from a high-throughput screening (HTS) perspective
    2013
  • Dominik Ausbacher, Janni Kujala, Pia M. Vuorela, Morten B. Strøm, Adyary Fallarero :
    Control of Staphylococcus aureus biofilm with highly active β2,2-amino acid derivatives
    2012
  • Leena Pohjala, Dominik Ausbacher, Morten B. Strøm, Pia M. Vuorela :
    Inhibition of Chlamydia pneumoniae infectivity by β-amino acid derivatives mimicking cationic antimicrobial peptides
    2012
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic β-peptidomimetics
    2011
  • Dominik Ausbacher, Terkel Hansen, Gunbjørg Svineng, Morten B. Strøm :
    Mechanisms of cancer cell death induced by two novel cationic beta-peptidomimetics
    Biopolymers 2011
  • Terkel Hansen, Dominik Ausbacher, Martina Havelkova, Morten B. Strøm :
    Bactericidal activity of small β-peptidomimetics
    2010

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