Bilde av West, Alex
Bilde av West, Alex
Árktalaš ja mariinna biologiija instituhtta alexander.c.west@uit.no +4777645219 You can find me here

Alex West



  • Chiara Ciccone, Fayiri Kante, Lars Folkow, David Grey Hazlerigg, Alexander Christopher West, Shona Hiedi Wood :
    Circadian coupling of mitochondria in a deep-diving mammal
    bioRxiv 2023 DOI
  • David Grey Hazlerigg, Barbara Mizumo Tomotani, Alexander Christopher West, Daniel Appenroth, Shona Hiedi Wood :
    Biological timekeeping in polar environments: lessons from terrestrial vertebrates
    Journal of Experimental Biology 2023 DOI
  • Alexander Christopher West, Yasutaka Mizoro, Shona Wood, Louise M. Ince, Marianne Iversen, Even Hjalmar Jørgensen et al.:
    Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics
    Frontiers in Immunology 2021 ARKIV / DOI
  • Marianne Iversen, Teshome Dagne Mulugeta, Alexander Christopher West, Even Hjalmar Jørgensen, Samuel A. M. Martin, Simen Rød Sandve et al.:
    Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar)
    G3: Genes, Genomes, Genetics 2021 ARKIV / DOI
  • Daniel Appenroth, Gabriela Wagner, David Hazlerigg, Alexander Christopher West :
    Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird
    Current Biology 21. Jun 2021 ARKIV / DOI
  • Daniel Appenroth, Vebjørn Jacobsen Melum, Alexander Christopher West, Hugues Dardente, David Hazlerigg, Gabriela Wagner :
    Photoperiodic induction without light-mediated circadian entrainment in a High Arctic resident bird
    Journal of Experimental Biology 21. Aug 2020 ARKIV / DOI
  • Marianne Iversen, Teshome Dagne Mulugeta, Børge Gellein Blikeng, Alexander Christopher West, Even Hjalmar Jørgensen, Simen Rød Sandve et al.:
    RNA profiling identifies novel, photoperiodhistory dependent markers associated with enhanced saltwater performance in juvenile Atlantic salmon
    PLOS ONE 2020 ARKIV / DOI
  • Alexander Christopher West, Marianne Iversen, Even Hjalmar Jørgensen, Simen Rød Sandve, David Hazlerigg, Shona Hiedi Wood :
    Diversified regulation of circadian clock gene expression following whole genome duplication
    PLoS Genetics 2020 ARKIV / DOI
  • Alexander Christopher West, Yasutaka Mizoro, Shona Hiedi Wood, Marianne Iversen, Louise Ince, Even Jørgensen et al.:
    A single nuclei transcriptomic analysis of the Atlantic salmon gill through smoltification and seawater transfer
    bioRxiv 2020 DOI
  • Shona Hiedi Wood, Alexander Christopher West :
    Seasonal physiology: making the future a thing of the past
    Current Opinion in Physiology 2018 DOI
  • Alexander Christopher West, Laura Smith, David Ray, Andrew S.I. Loudon, Tim Brown, David A. Bechtold :
    Misalignment with the external light environment drives metabolic and cardiac dysfunction
    Nature Communications 2017 DOI
  • Alexander Christopher West, David A. Bechtold :
    The cost of circadian desynchrony: Evidence, insights and open questions
    Bioessays 2015 DOI
  • Lauren Walmsley, Lydia Hanna, Josh Mouland, Franck Marshall, Alexander Christopher West, Andrew R.D. Smedley et al.:
    Colour as a signal for entraining the mammalian circadian clock
    PLoS Biology 2015 DOI
  • Violetta Pilorz, Peter Cunningham, Anthony Jackson, Alexander Christopher West, Travis Wager, Andrew S.I. Loudon et al.:
    A Novel Mechanism Controlling Resetting Speed of the Circadian Clock to Environmental Stimuli
    Current Biology 2014 DOI
  • Alexander Christopher West, Sandrine M Dupre, Le Yu, Robert Patton, K Miedzinska, Alan McNeilly et al.:
    Npas4 Is Activated by Melatonin, and Drives the Clock Gene Cry1 in the Ovine Pars Tuberalis
    Molecular Endocrinology 2013 DOI
  • Chiara Ciccone, Fayiri Kante, David Grey Hazlerigg, Lars Folkow, Alexander Christopher West, Shona Hiedi Wood :
    Circadian clockwork and mitochondrial metabolism in a diving mammal: a link between hypoxia tolerance and time of the day
    2022
  • Alexander Christopher West, David Hazlerigg, Gabrielle Grenier :
    Calendar Timing in Teleost Fish
    Springer Nature 2021 DOI

  • The 50 latest publications is shown on this page. See all publications in Cristin here →

    Publications outside Cristin

    Publications from the last five years:

    • Appenroth D, Wagner G, Hazlerigg DG, West AC (2021). Evidence for circadian-based photoperiodic timekeeping in Svalbard ptarmigan, the northernmost resident bird. Current Biology, 31, 2720–2727.
    • West AC, Mizoro Y, Wood SH, Ince L, Iversen M, Jørgensen E, Nome T, Sandve SR, Loudon ASI, Hazlerigg DG (2021). Immunologic Profiling of the Atlantic Salmon Gill by Single Nuclei Transcriptomics. Frontiers in Immunology, 4;12:669889.
    • Iversen M, Mulugeta T, West AC, Jørgensen E, Martin SAM, Sandve SR, Hazlerigg DG (2021) Photoperiod-dependent developmental reprogramming of the transcriptional response to seawater entry in Atlantic salmon (Salmo salar). G3. 11(4):jkab072.
    • West AC, Iversen M, Jørgensen E, Sandve SR, Hazlerigg DG, Wood SH (2020) Diversified regulation of circadian clock gene expression following whole genome duplication. PLoS Genetics, 16(10): e1009097.
    • Iversen M, Mulugeta T, Blikeng BG, West AC, Hazlerigg D, and Jørgensen EH (2020) RNA profiling identifies novel, photoperiod-history dependent markers associated with enhanced saltwater performance in juvenile Atlantic salmon. PLoS One. Apr 8:15(4):e0227496.
    • Appenroth D, Melum VJ, West AC, Dardente H, Hazlerigg DG and Wagner G (2020) Photoperiodic induction without light-mediated circadian entrainment in a High Arctic resident bird. Accepted in Journal of Experimental Biology.
    • West AC, Wood SH (2018) Seasonal physiology: making the future a thing of the past. Current Opinions in Physiology, 5:1-8
    • West AC, Smith L, Ray DW, Loudon ASI, Brown TM, Bechtold DA (2017) Misalignment with the external light environment drives metabolic and cardiac dysfunction. Nature Communications, 8(1):417.


    Dutkanberoštumit

    The most interesting animals transform their physiology to cope/exploit seasonal changes in their environment; nowhere is this more apparent than in the Arctic. By combining classical experimental designs with cutting edge tools, my research aims to identify the pathways that control seasonal transformation and explores how biological timekeeping is influenced by the Arctic environment.

    Current projects:

    • Seasonal regulation of pituitary prolactin
    • Seasonal control of reproduction in birds
    • Arctic circadian clocks
    • Seasonal control of smoltification in Atlantic salmon

    Undervisning

    Teaching:

    • BIO-3014: Biological Timekeeping (Co-pilot 2021, Pilot 2022)
    • BIO-3030: Extreme Physiology
    • BIO-2002: Animal Physiology
    • BIO-2310: Arctic Biology (-2022)


     PhD Supervision

    • Anna Hofinger (2022-2026) - Seasonal regulation of pituitary prolactin. Supervisors: Alex West, Shona Wood
    • Jana Kalinova (2021-2025) - Photoperiodic control of reproduction in birds. Supervisors: David Hazlerigg, Alex West, Shona Wood
    • Daniel Appenroth (2016-2020) - Circadian-based processes in the High Arctic: activity, thermoregulation and photoperiodism in the Svalbard ptarmigan (Lagopus muta hyperborea). Supervisors: David Hazlerigg, Gabriela Wagner, Alex West

    Masters Supervision

    • Sona Hakhverdyan (2022-2023) - In vivo CRISPR of CUZD1 in Atlantic salmon. Supervisors: Alex West, Helge Tveiten
    • Therese Solberg (2021-2022) - Circadian disruption by light and its effect on the immune function of the Atlantic salmon (Salmo salar). Supervisors: Alex West, Eva-Stina Edholm, David Hazlerigg
    • Anna Hofinger (2020-2021) - Characterization of the biological clock in Svalbard ptarmigan (Lagopus muta hyperborea). Supervisors: David Hazlerigg, Alex West
    • Fayiri Kante (2020-2021) - Characterization of the circadian clock in Hooded Seals (Cystophora Cristata) and its interaction with mitochondrial metabolism: A multi-tissue comparison and cell culture approach. Supervisors: Shona Wood, Alex West
    • Vebjørn Melum (2017-2018) - Influence of photoperiod on central appetite regulation in captive Svalbard rock ptarmigan (Lagopus muta hyperborea) 
    • Nora Slåttebrekk (2017-2018) -  An analysis of key molecular clock components in reindeer (Rangifer t. tarandus). Supervisors: Gabriela Wagner, Alex West, David Hazlerigg




    Attachments:

    • CV (docx)