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Photo: Art of moments
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Árktalaš ja mariinna biologiija instituhtta ines.heiland@uit.no +4777646889 Tromsø Biologibygget 2.052

Ines Heiland



  • Panitz, Verena; Končarević, Saša; Sadik, Ahmed; Friedel, Dennis; Bausbacher, Tobias; Trump, Saskia; Farztdinov, Vadim; Schulz, Sandra; Sievers, Philipp; Schmidt, Stefan; Jürgenson, Ina; Jung, Stephan; Kuhn, Karsten; Pflüger, Irada; Sharma, Suraj; Wick, Antje; Pfänder, Pauline; Selzer, Stefan; Vollmuth, Philipp; Sahm, Felix; von Deimling, Andreas; Heiland, Ines; Hopf, Carsten; Schulz-Knappe, Peter; Pike, Ian; Platten, Michael; Wick, Wolfgang; Opitz, Christiane A.. Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma. Theranostics 2021; Volum 11 (19). ISSN 1838-7640.s 9217 - 9233.s doi: 10.7150/thno.60679.
  • Ziegler, Mathias; Monnè, Magnus; Nikiforov, Andrey; Agrimi, Gennaro; Heiland, Ines; Palmieri, Ferdinando. Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25. Biomolecules 2021; Volum 11 (6). ISSN 2218-273X.s doi: 10.3390/biom11060880.
  • Dietze, Jørn; van Pijkeren, Alienke; Egger, Anna-Sophia; Ziegler, Mathias; Kwiatkowski, Marcel; Heiland, Ines. Natural isotope correction improves analysis of protein modification dynamics. Analytical and Bioanalytical Chemistry 2021; Volum 413. ISSN 1618-2642.s 7333 - 7340.s doi: 10.1007/s00216-021-03732-7.
  • Van Pijkeren, Alienke; Dietze, Jørn; Brotons, Alejandro Sánchez; Egger, Anna-Sophia; Lijster, Tim; Barcaru, Andrei; Hotze, Madlen; Kobler, Philipp; Dekker, Frank J.; Horvatovich, Peter; Melgert, Barbro N.; Ziegler, Mathias; Thedieck, Kathrin; Heiland, Ines; Bischoff, Rainer; Kwiatkowski, Marcel. Combined metabolic and chemical (CoMetChem) labeling using stable isotopes - A strategy to reveal site-specific histone acetylation and deacetylation rates by LC-MS. Analytical Chemistry 2021; Volum 93 (38). ISSN 0003-2700.s 12872 - 12880.s doi: 10.1021/acs.analchem.1c01359.
  • Mohapatra, Soumya R; Sadik, Ahmed; Sharma, Suraj; Poschet, Gernot; Gegner, Hagen M; Lanz, Tobias V; Lucarelli, Philippe; Klingmüller, Ursula; Platten, Michael; Heiland, Ines; Opitz, Christiane A.. Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production. (fulltekst) Frontiers in Immunology 2021; Volum 12. ISSN 1664-3224.s doi: 10.3389/fimmu.2021.590532.
  • Prentzell, Mirja Tamara; Rehbein, Ulrike; Sandoval, Marti Cadena; De Meulemeester, Ann-Sofie; Baumeister, Ralf; Brohée, Laura; Berdel, Bianca; Bockwoldt, Mathias; Carroll, Bernadette; Chowdhury, Suvagata Roy; von Deimling, Andreas; Demetriades, Constantinos; Figlia, Gianluca; de Arauj, Mariana Eca Guimaraes; Heberle, Alexander Martin; Heiland, Ines; Holzwarth, Birgit; Huber, Lukas A; Jaworski, Jacek; Kedra, Magdalena; Kern, Katharina; Kopach, Andrii; Korolchuk, Viktor I; van't Land-Kuper, Ineke; Macias, Matylda; Nellist, Mark; Palm, Wilhelm; Pusch, Stefan; Ramos Pittol, Jose Miguel; Reil, Michèle; Reintjes, Anja; Reuter, Friederike; Sampson, Julian R.; Scheldeman, Chloë; Siekierska, Aleksandra; Stefan, Eduard; Teleman, Aurelio A; Thomas, Laura E; Torres-Quesada, Omar; Trump, Saskia; West, Hannah D; de Witte, Peter; Woltering, Sandra; Yordanov, Teodor E; Zmorzynska, Justyna; Opitz, Christiane A.; Thedieck, Kathrin. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. (fulltekst) (omtale) (prosjekt) Cell 2021; Volum 184. ISSN 0092-8674.s 655 - 674.s doi: 10.1016/j.cell.2020.12.024.
  • Mohapatra, Soumya R.; Sadik, Ahmed; Tykocinski, Lars-Oliver; Dietze, Jørn; Poschet, Gernot; Heiland, Ines; Opitz, Christiane A.. Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma. Frontiers in Immunology 2019; Volum 10. ISSN 1664-3224.s 1 - 13.s doi: 10.3389/fimmu.2019.02762.
  • Clarelli, Fabrizio; Liang, Jingyi; Martinecz, Antal; Heiland, Ines; Abel zur Wiesch, Pia. Multi-scale modeling of drug binding kinetics to predict drug efficacy. Cellular and Molecular Life Sciences (CMLS) 2019. ISSN 1420-682X.s doi: 10.1007/s00018-019-03376-y.
  • Heberle, Alexander Martin; Razquin Navas, Patricia; Langelaar-Makkinje, Miriam; Kasack, Katharina; Sadik, Ahmed; Faessler, Erik; Hahn, Udo; Marx-Stoelting, Philip; Opitz, Christiane A.; Sers, Christine; Heiland, Ines; Schaeuble, Sascha; Thedieck, Kathrin. The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner. Life Science Alliance (LSA) 2019; Volum 2 (2). ISSN 2575-1077.s doi: 10.26508/lsa.201800257.
  • Bockwoldt, Mathias; Houry, Dorothee; Niere, Marc; Gossmann, Toni I.; Reinartz, Ines; Schug, Alexander; Ziegler, Mathias; Heiland, Ines. Identification of evolutionary and kinetic drivers of NAD-dependent signaling. Proceedings of the National Academy of Sciences of the United States of America 2019; Volum 116 (32). ISSN 0027-8424.s 15957 - 15966.s doi: 10.1073/pnas.1902346116.
  • Bockwoldt, Mathias; Heiland, Ines; Fischer, Karsten. The evolution of the plastid phosphate translocator family. Planta 2019; Volum 250 (1). ISSN 0032-0935.s 245 - 261.s doi: 10.1007/s00425-019-03161-y.
  • Strømland, Øyvind; Niere, Marc; Nikiforov, Andrey; Van Linden, Magali R; Heiland, Ines; Ziegler, Mathias. Keeping the balance in NAD metabolism. Biochemical Society Transactions 2019; Volum 47 (1). ISSN 0300-5127.s 119 - 130.s doi: 10.1042/BST20180417.
  • Adam, Isabell; Dewi, Dyah L.; Mooiweer, Joram; Sadik, Ahmed; Mohapatra, Soumya R.; Berdel, Bianca; Keil, Melanie; Sonner, Jana K.; Thedieck, Kathrin; Rose, Adam J.; Platten, Michael; Heiland, Ines; Trump, Saskia; Opitz, Christiane A.. Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation. Oncoimmunology 2018; Volum 7 (12). ISSN 2162-4011.s 1 - 15.s doi: 10.1080/2162402X.2018.1486353.
  • Afanasyeva, Arina; Bockwoldt, Mathias; Cooney, Christopher; Heiland, Ines; Gossmann, Toni Ingolf. Human long intrinsically disordered protein regions are frequent targets of positive selection. Genome Research 2018; Volum 28 (7). ISSN 1088-9051.s 975 - 982.s doi: 10.1101/gr.232645.117.
  • Dewi, Dyah L; Mohapatra, Soumya R; Cabañes, Saioa Blanco; Adam, Isabell; Patterson, Luis F Somarribas; Berdel, Bianca; Kahloon, Masroor; Thürmann, Loreen; Loth, Stefanie; Heilmann, Katharina; Weichenhan, Dieter; Mucke, Oliver; Heiland, Ines; Wimberger, Pauline; Kuhlmann, Jan Dominik; Kellner, Karl-Heinz; Schott, Sarah; Plass, Christoph; Platten, Michael; Gerhäuser, Clarissa; Trump, Saskia; Opitz, Christiane A.. Suppression of indoleamine-2, 3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. Oncoimmunology 2017; Volum 6 (2). ISSN 2162-4011.s doi: 10.1080/2162402X.2016.1274477.
  • Schäuble, Sascha; Stavrum, Anne-Kristin; Bockwoldt, Mathias; Puntervoll, Pål; Heiland, Ines. SBMLmod: a Python-based web application and web service for efficient data integration and model simulation. (fulltekst) BMC Bioinformatics 2017; Volum 18 (314). ISSN 1471-2105.s 1 - 8.s doi: 10.1186/s12859-017-1722-9.
  • Opitz, Christiane A.; Heiland, Ines. Dynamics of NAD-metabolism: everything but constant. Biochemical Society Transactions 2015; Volum 43 (6). ISSN 0300-5127.s 1127 - 1132.s doi: 10.1042/BST20150133.
  • Heiland, Ines; Thedieck, K. Nutrigenomics: Toward a cross-disciplinary understanding of nutrient-driven networks in health and disease: What can we learn from the study of cross-talk in complex protein kinase and metabolic networks?. Aktuelle Ernãhrungsmedizin 2015; Volum 40 (2). ISSN 0341-0501.s 88 - 92.s doi: 10.1055/s-0034-1387602.
  • Wencke, Walter; Ketelsen, Bernd; Emmanuel, Gaquerel; Baldwin, Ian T.; Sang-Gyu, Kim; Heiland, Ines. Improving the accuracy of expression data analysis in time course experiments using resampling. (fulltekst) BMC Bioinformatics 2014; Volum 15. ISSN 1471-2105.s doi: 10.1186/s12859-014-0352-8.
  • Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan; Puntervoll, Pål; Ziegler, Mathias. Model of tryptophan metabolism, readily scalable using tissue-specific gene expression data. Journal of Biological Chemistry 2013; Volum 288 (48). ISSN 0021-9258.s 34555 - 34566.s doi: 10.1074/jbc.M113.474908.
  • Schmeisser, Kathrin; Mannsfeld, Johannes; Kuhlow, Doreen; Weimer, Sandra; Priebe, Steffen; Heiland, Ines; Birringer, Marc; Groth, Marco; Segref, Alexandra; Kanfi, Yariv; Price, Nathan L.; Schmeisser, Sebastian; Schuster, Stefan; Pfeiffer, Andreas F. H.; Guthke, Reinhard; Platzer, Matthias; Hoppe, Torsten; Haim, Cohen Y; Zarse, Kim; Sinclair, David A; Ristow, Michael. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chemical Biology 2013; Volum 9 (11). ISSN 1552-4450.s 693 - 700.s doi: 10.1038/nchembio.1352.
  • Schäuble, Sascha; Stavrum, Anne-Kristin; Puntervoll, Pål; Schuster, Stefan; Heiland, Ines. Effect of substrate competition in kinetic models of metabolic networks. (fulltekst) FEBS Letters 2013; Volum 587 (17). ISSN 0014-5793.s 2818 - 2824.s doi: 10.1016/j.febslet.2013.06.025.
  • Heiland, Ines; Kaleta, Christoph. Stoffwechselanalyse: Neue Wege im Labyrinth entdecken. Laborwelt 2012; Volum 4. ISSN 1611-0854.s 30 - 32.
  • Zupanic, Anze; Bernstein, Hans Christopher; Heiland, Ines. Systems biology – Current status and challenges. Cellular and Molecular Biology 2020; Volum 77 (3). ISSN 0145-5680.s 379 - 380.s doi: 10.1007/s00018-019-03410-z.
  • Bockwoldt, Mathias; Heiland, Ines; Gossmann, Toni Ingolf; Rattei, Thomas. Sequence-Based Analysis of Eukaryotic Protein Evolution. 2018 ISBN 9788282661591.
  • Sauter, Roland; Heiland, Ines. Arctic Marine Bioplastics. 3rd annual meeting of NORBIS 2017-08-08 - 2017-08-10 2017.
  • Gossmann, Toni Ingolf; Afanasyeva, Arina; Bockwoldt, Mathias; Heiland, Ines; Chris, Cooney. Human intrinsically long disordered protein regions are frequent targets of positive selection. Annual Meeting of the Society for Molecular Biology and Evolution 2017 2017-07-02 - 2017-07-06 2017.
  • Sauter, Roland; Heiland, Ines. Metabolic Modeling of Marine Biomass Conversion. 1st annual BioCat Meeting 2016-06-12 - 2016-06-14 2016.
  • Heiland, Ines; Bockwoldt, Mathias; Puntervoll, Pål; Schäuble, Sascha; Stavrum, Anne-Kristin. Tissue specific models of Trp- and NAD-metabolism — insights into metabolic crosstalk.. 2016 Conference on Computational Modelling with COPASI 2016-05-12 - 2016-05-13 2016.
  • Bockwoldt, Mathias; Heiland, Ines; Toni, Gossmann; Ziegler, Mathias. Phylogenetic and simulation-based analysis of NAD metabolism. ISGSB 2016 2016-10-04 - 2016-10-07 2016.
  • Heiland, Ines; Bockwoldt, Mathias; Stavrum, Anne-Kristin; Puntervoll, Pål; Ziegler, Mathias. Tissue specific models of Tryptohan-metabolism — insights into metabolic crosstalk. COPASI User conference 2016-05-12 - 2016-05-13 2016.
  • Bockwoldt, Mathias; Heiland, Ines. Phylogenetic Analysis of NAD biosynthesis and consumption. NBS contact meeting 2016-01-21 - 2016-01-23 2016.
  • Bockwoldt, Mathias; Heiland, Ines. Use of resampling to improve accuracy of data analysis in time course experiments. European Biological Rhythms Sociecty Congress and World Congress of Chronobiology 2015-08-02 - 2015-08-06 2015.
  • Bockwoldt, Mathias; Heiland, Ines. Phylogenetic Analysis of NAD biosynthesis and consumption. Norbis Annual Meeting 2015-10-28 - 2015-10-30 2015.
  • Elliss, Carolyn; Rattei, Thomas; Heiland, Ines. 50 Years of FEBS´ Education Training Awards. (fulltekst) FEBS News 2015; Volum 2015 (2).s 15 - 16.
  • Bockwoldt, Mathias; Stavrum, Anne-Kristin; Gossmann, Toni I.; Ziegler, Mathias; Heiland, Ines. Dynamics of NAD-metabolism - everything but constant. Metabolic Pathway Analysis (omtale) 2015-06-08 - 2015-06-12 2015.
  • Heiland, Ines. Chemo Informatik: Was hat Tryptophan mit Krebs und Parkinson zu tun?. Chemie in unserer Zeit 2014; Volum 48 (3). ISSN 0009-2851.s 164 - 166.s doi: 10.1002/ciuz.201480013.
  • Walter, Wencke; Gaquerel, Emmanuel; Baldwin, Ian T.; Kim, Sang-Gyu; Heiland, Ines. Improving the analysis of high throughput time course data using modelling based approaches. SocBin Bioinformatics 2014-06-11 - 2014-06-13 2014.
  • Stavrum, Anne-Kristin; Heiland, Ines; Schuster, Stefan; Puntervoll, Pål; Ziegler, Mathias. Predicting pathological metabolic changes using a kinetic model of tryptophan metabolism. Advanced Lecture Course on Systems Biology 2014-03-02 - 2014-03-08 2014.
  • Heiland, Ines; Brandes, Susanne; Stavrum, Anne-Kristin; Bodenstein, Christian; Ziegler, Mathias. NAD-metabolism and the circadian clock -- Unraveling contradictions. Advanced Lecture Course on Systems Biology 2014-03-02 - 2014-03-08 2014.
  • Heiland, Ines. Metabolic modelling: From networks to dynamics and back. Workshop on Visualization in Biology 2013-09-19 - 2013-09-19 2013.
  • Heiland, Ines; Brandes, Susanne; Stavrum, Anne-Kristin; Bodenstein, Christian; Ziegler, Mathias. NAD-metabolism and the circadian clock. Gordon Conference Chronobiology 2013-07-14 - 2013-07-19 2013.
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    Biologibygget 2.052

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