Discovery of Antibiotic Resistance in Newly Identified Bacterium

Staphylococcus borealis has been found to be resistant to several different types of antibiotics, posing a potentially significant problem for the elderly.

In 2020, a research group at UiT The Arctic University of Norway in Tromsø discovered a previously unknown bacterium. You may have heard of Staphylococcus aureus (golden staph), but this one belongs to the white variety. 

The newcomer, discovered in Tromsø in Northern Norway, was proudly named Staphylococcus borealis (S. borealis) after the Northern Lights.

But how dangerous is it really, and is it a threat to us at all? 

33 Percent Antibiotic Resistance

To investigate, researchers collected bacterial samples stored in freezers at several Norwegian hospitals.

The samples went as far back as 2014, and the researchers conducted new tests to see if they could identify the new bacterium in the old samples. Meanwhile, new samples arriving at the UiT lab from 2020 to 2024 were tested continuously. In total, the researchers collected and analysed 129 samples from seven Norwegian hospitals.

It turns out that S. borealis is resistant to more than three different classes of antibiotics in one-third of the cases where it was tested. 

"We see the most resistance against the antibiotic classes fusidic acid, cephalosporins, penicillins, macrolides, and fluoroquinolones," explains Jorunn Pauline Cavanagh, who led the work on bacterial analyses.

Moreover, the bacterium also appears to be highly adept at acquiring protective mechanisms from other bacterial species. This means it could potentially develop antibiotic resistance quickly, when attacked with the medicines currently available.

A Problem for the Elderly

S. borealis is a bacterium that lives on our skin, and researchers have found that it can become problematic when your immune system is weakened. This makes it particularly concerning for the elderly and for those who have had knee or hip replacements. 

"This bacterium is an opportunist that can cause illness when your immune system is compromised. For example, we see that it can form what’s called biofilm around knee prostheses and cause infections that can be difficult to treat," explains Jorunn Pauline Cavanagh. 

Researchers are now working to determine which diseases this bacterium can cause. Preliminary findings suggest it may lead to urinary tract infections, as well as inflammation in areas where implants are present.

"We do know that it causes mastitis in dromedary camels. This is because we’ve published the bacterium’s genetic profile in international databases, which other researchers use to compare their own bacterial findings. So, more possibilities may emerge," says Cavanagh.

Contact Information

Jorunn Pauline Cavanagh
Associate professor at UiT The Arctic University of Norway
Phone: +47 40 49 84 90

Scientific Reference

https://journals.asm.org/doi/10.1128/spectrum.01988-24

CANS migrates from X to Bluesky. Click to join us.

Bacterial breakthrough in the Arctic Sea

Researchers from CANS and the research group Marbio have found antibacterial compounds in the Barents Sea, a new study shows.

During a research trip off Svalbard with the Norwegian research vessel FF Kronprins Haakon in 2020, UiT researchers came across actinobacteria in sediments and marine life. After laboratory analysis, the researchers have concluded that the bacteria contain compunds that disarm enteropathogenic E. coli bacteria, which is responsible for intestinal infections and infant mortality in developing countries. 

Read the news story in The National: 
https://www.thenationalnews.com/future/science/2024/08/30/how-the-arctic-could-unlock-secrets-of-antibiotic-resistance/

Download the scientific article from Frontiers in microbiology: 
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1432475/full

Contact information
Dr. Yannik Schneider
yannik.k.schneider@uit.no
https://uit.no/ansatte/yannik.k.schneider

Arnfinn Sundsfjord  –  Professor

Kontaktperson for AMR Bridge, og ansvarlig for prosjektet ledet fra Tromsø.

Pål Jarle Johnsen  –  Professor

Lars Ailo Bongo  –  Professor

Klara Stensvåg  –  Professor

Jørgen Berge  –  Dean

Gunbjørg Svineng  –  Dean

Arne O. Smalås  –  Dean

Benjamin P. Howden  –  Professor

Deniz Tasdemir  –  Professor

Ursula Theuretzbacher  –  Dr.

Jörgen Johansson  –  Professor