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Photo: Bjørn-Kåre Iversen

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Ole Morten Seternes

Professor
Farmasiija instituhtta




Arbeider i CRIStin


  • Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli. Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. Journal of Medicinal Chemistry 2018; Volum 61 (17). ISSN 0022-2623.s 7560 - 7572.s doi: 10.1021/acs.jmedchem.7b01847.

  • Seternes, Ole Morten; Kidger, Andrew M; Keyse, Stephen M. Dual-specificity MAP kinase phosphatases in health and disease. BBA - Molecular Cell Research 2018. ISSN 0167-4889.s doi: 10.1016/j.bbamcr.2018.09.002.

  • Perander, Maria; Al-Mahdi, Rania; Jensen, Thomas Clemens; Nunn, Jennifer Ann Lillebo; Kildalsen, Hanne; Johansen, Bjarne Herold; Gabrielsen, Mads; Keyse, Stephen M; Seternes, Ole Morten. Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2. Scientific Reports 2017; Volum 7. ISSN 2045-2322.s doi: 10.1038/srep43471.

  • Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Seternes, Ole Morten; Bang, Berit. Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549). Toxicology and industrial health 2016; Volum 32 (11). ISSN 0748-2337.s 1866 - 1874.s doi: 10.1177/0748233715590914.

  • Perander, Maria; Keyse, Stephen M; Seternes, Ole Morten. New insights into the activation, interaction partners and possible functions of MK5/PRAK. Frontiers in Bioscience 2016; Volum 21 (2). ISSN 1093-9946.s 374 - 384.

  • Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, maria; Seternes, Ole Morten. Distinct small RNA signatures in extracellular vesicles derived from breast cancer cell lines. PLOS ONE 2016; Volum 11 (8). ISSN 1932-6203.s doi: 10.1371/journal.pone.0161824.

  • Whiting, Jennifer L.; Ogier, Leah; Forbush, Katherine A; Bucko, Paula; Gopalan, Janani; Seternes, Ole Morten; Langeberg, Lorene K.; Scott, John D.. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proceedings of the National Academy of Sciences of the United States of America 2016; Volum 113 (30). ISSN 0027-8424.s E4328 - E4337.s doi: 10.1073/pnas.1607745113.

  • Whiting, Jennifer L.; Nygren, Patrick J.; Tunquist, Brian J.; Langeberg, Lorene K.; Seternes, Ole Morten; Scott, John D.. Protein kinase A opposes the phosphorylation-dependent recruitment of glycogen synthase kinase 3β to A-kinase Anchoring Protein 220. Journal of Biological Chemistry 2015; Volum 290 (32). ISSN 0021-9258.s 19445 - 19457.s doi: 10.1074/jbc.M115.654822.

  • Al-Mahdi, Rania; Babteen, Nouf; Thillai, Kiruthikah; Holt, Mark; Johansen, Bjarne Herold; Wetting, Hilde Ljones; Seternes, Ole Morten; Wells, Claire. A novel role for atypical MAPK kinase ERK3 in regulating breast cancer cell morphology and migration. Cell Adhesion & Migration 2015; Volum 9 (6). ISSN 1933-6918.s 483 - 494.s doi: 10.1080/19336918.2015.1112485.

  • Bian, Ka; Muppani, Naveen Reddy; Elkhadragy, Lobna; Wang, Wei; Zhang, Cheng; Chen, Tenghui; Jung, Sungyun; Seternes, Ole Morten; Long, Weiwen. ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells. OncoTarget 2015; Volum 7 (6). ISSN 1949-2553.s 6665 - 6675.s doi: 10.18632/oncotarget.6682.

  • Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Winberg, Jan-Olof; Seternes, Ole Morten; Bang, Berit. Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line. Food and Chemical Toxicology 2014; Volum 69. ISSN 0278-6915.s 303 - 311.s doi: 10.1016/j.fct.2014.04.030.

  • Larsen, Anett Kristin; Kristiansen, kurt; Sylte, Ingebrigt; Seternes, Ole Morten; Bang, Berit. Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin. BMC Research Notes 2013; Volum 6. ISSN 1756-0500.s 281 - .s doi: 10.1186/1756-0500-6-281.

  • Knutsen, Erik; Fiskaa, Tonje; Ursvik, anita; Jørgensen, Tor Erik; Perander, maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar; Andreassen, morten. Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines. PLOS ONE 2013; Volum 8 (10). ISSN 1932-6203.s doi: 10.1371/journal.pone.0075813.

  • Urbarova, Ilona; Karlsen, Bård Ove; Okkenhaug, Siri; Seternes, Ole Morten; Johansen, Steinar; Emblem, Åse. Digital Marine Bioprospecting: Mining New Neurotoxin Drug Candidates from the Transcriptomes of Cold-Water Sea Anemones. Marine Drugs 2012; Volum 10 (10). ISSN 1660-3397.s 2265 - 2279.s doi: 10.3390/md10102265.

  • Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Kishimura, Hideki; Rudenskaya, Galina N; Bang, Berit. Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-kappa B-, and IL-8 signaling. Toxicological & Environmental Chemistry 2011; Volum 93 (10). ISSN 0277-2248.s 1991 - 2011.s doi: 10.1080/02772248.2011.614380.

  • Johansen, Steinar D.; Emblem, Åse; Karlsen, Bård Ove; Okkenhaug, Siri; Hansen, Hilde; Moum, Truls; Coucheron, Dag-Hugo; Seternes, ole morten. Approaching marine bioprospecting in hexacorals by RNA deep sequencing. New Biotechnology 2010; Volum 27 (3). ISSN 1871-6784.s 267 - 275.s doi: 10.1016/j.nbt.2010.02.019.

  • Seternes, ole morten; Johansen, Bjarne Herold; Hegge, Beate; Johannessen, Mona; Keyse, Stephen M; Moens, Ugo. Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress. Molecular and Cellular Biology 2010; Volum 22 (20). ISSN 0270-7306.s 6931 - 6945.s doi: 10.1128/MCB.22.20.6931-6945.202.

  • Åberg, espen; Torgersen, Knut Martin; Johansen, Bjarne Herold; Keyse, Stephen M; Perander, maria; Seternes, ole morten. Docking of PRAK/MK5 to the Atypical MAPKs ERK3 and ERK4 Defines a Novel MAPK Interaction Motif. Journal of Biological Chemistry 2009; Volum 284 (29). ISSN 0021-9258.s 19392 - 19401.s doi: 10.1074/jbc.M109.023283.

  • Perander, maria; Åberg, espen; Johansen, Bjarne Herold; Dreyer, Bo; Guldvik, Ingrid Jenny; Outzen, heidi; Keyse, Stephen M; Seternes, ole morten. The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5. Biochemical Journal 2008; Volum 411. ISSN 0264-6021.s 613 - 622.s doi: 10.1042/BJ20071369.

  • Hansen, Tom Egil; Puntervoll, Pål; Borgland, A.W.; Seternes, ole morten; Eigen, Gerald; Jørgensen, Jorunn B; Frodesen, A.G.; Keranen, R.; Stugu, Bjarne; et al., DELPHI Collaboration. Atlantic salmon possess three mitogen activated protein kinase kinase 6 paralogs responding differently to stress. The FEBS Journal 2008; Volum 275. ISSN 1742-464X.s 4887 - 4902.s doi: 10.1111/j.1742-4658.2008.06628.x.

  • Larsen, Anett Kristin; Seternes, ole morten; Larsen, Merethe; Aasmoe, lisbeth; Bang, Berit. Salmon trypsin stimulates the expression of interleukin-8 via protease-activated receptor-2. Toxicology and Applied Pharmacology 2008; Volum 230. ISSN 0041-008X.s 276 - 282.s doi: 10.1016/j.taap.2008.02.019.

  • Perander, maria; Keyse, Stephen M; Seternes, ole morten. Does MK5 reconcile classical and atypical MAP kinases?. Frontiers in Bioscience 2008; Volum 13. ISSN 1093-9946.s 4617 - 4624.

  • Michaelsen, espen; Perander, maria; Johansen, Bjarne Herold; Julien, Catherine; Meloche, Sylvain; Keyse, Stephen M; Seternes, ole morten. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. Journal of Biological Chemistry 2006; Volum 281 (46). ISSN 0021-9258.s 35499 - 35510.

  • Hendrickx, Nico; Volanti, Cédric; Moens, Ugo; Seternes, ole morten; De Witte, Peter; Vandenheede, Jackie R. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. Journal of Biological Chemistry 2004; Volum 278. ISSN 0021-9258.s 52231 - 52239.

  • Seternes, Ole Morten; Mikalsen, Theresa; Johansen, Bjarne; Michaelsen, Espen; Armstrong, CG; Morrice, NA; Turgeon, B; Meloche, S; Moens, Ugo Lionel; Keyse, SM. Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO Journal 2004; Volum 23 (24). ISSN 0261-4189.s 4780 - 4791.s doi: 10.1038/sj.emboj.7600489.

  • Johannessen, Mona; Delghandi, Marit Pedersen; Seternes, Ole Morten; Johansen, Bjarne; Moens, Ugo Lionel. Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain. Cellular Signalling 2004; Volum 16 (10). ISSN 0898-6568.s 1187 - 1199.

  • Johannessen, Mona; Olsen, Petter Angell; Johansen, Bjarne; Seternes, Ole Morten; Moens, Ugo Lionel. Activation of the coactivator foru-and-a-half-LIM-only protein FHL2 and the c-fos promoter through inhibition of protein phosphatase 2A. Biochemical Pharmacology 2003; Volum 65. ISSN 0006-2952.s 1317 - 1328.

  • Johannessen, Mona; Olsen, Petter Angell; Sørensen, Rita Irene; Johansen, Bjarne; Seternes, Ole Morten; Moens, Ugo Lionel. A role of the TATA box and the general co-activator hTAFII130/135 in promoter-specific trans-activation by simian virus 40 small t antigen. Journal of General Virology 2003; Volum 84. ISSN 0022-1317.s 1887 - 1897.s doi: 10.1099/vir.0.19057-0.

  • Hendrickx, Nico; Volanti, Cédric; Moens, Ugo Lionel; Seternes, Ole Morten; De Witte, Peter; Vandenheede, Jackie R; Piette, Jacques; Agostini, Patrizia. Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells. Journal of Biological Chemistry 2003; Volum 278 (52). ISSN 0021-9258.s 52231 - 52239.s doi: 10.1074/jbc.M307591200.

  • Kristoffersen, Anne Karin; Johnsen, Jon Inge; Seternes, Ole Morten; Rollag, Halvor; Degre, Miklos; Traavik, Terje. The human polyomavirus BK T antigen induces gene expression in human xcytomegalovirus. Virus Research 1997; Volum 52. ISSN 0168-1702.s 61 - 71.

  • Sveinbjørnsson, Baldur; Olsen, randi; Seternes, Ole Morten; Seljelid, rolf. Macrophage Cytotoxicity against Murine Meth A Sarcoma Involves Nitric Oxide-Mediated Apoptosis. Biochemical and Biophysical Research Communications - BBRC 1996; Volum 223. ISSN 0006-291X.s 643 - 649.

  • Bang, Berit; Larsen, Anett Kristin; Bhagwat, Sampada Satchidanand; Malla, Nabin; Seternes, Ole Morten; Winberg, Jan-Olof. Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.. Regional Helsekonferanse 2016-11-02 - 2016-11-03 2016.

  • Bang, Berit; Larsen, Anett Kristin; Bhagwat, Sampada Satchidanand; Malla, Nabin; Seternes, Ole Morten; Winberg, Jan-Olof. Seafood proteases present in workplace bioaerosols – effects on inflammatory pathways in skin and airway cell models.. EAACI 2016 2016-06-12 - 2016-06-16 2016.

  • Åberg, espen; Seternes, Ole Morten; Engh, Richard Alan; Gruber, Franz. Fra Mutasjon til Medisin. Forskningsdagene i Tromsø 2013 - Kreftforeningens Stand 2013-09-20 - 2013-09-21 2013.

  • Perander, maria; Stiberg, Trine; Myhren, Lene Elisabeth; Hansen, Espen; Seternes, ole morten; Herfindal, Lars; Andersen, Jeanette hammer; Jørgensen, Trond Ø.. Characterization of cytotoxic activities in extracts from two marine invertebrates. Bioprosp 2011 2011-02-23 - 2011-02-25 2011.

  • Knutsen, Erik; Andreassen, morten; Fiskaa, Tonje; Ursvik, anita; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar Daae. MiRNA expression profiling based on different high-throughput platforms reveals surprising variations. ncRNAs and Human Disease International symposium 2011-08-25 - 2011-08-26 2011.

  • Larsen, Anett Kristin; Larsen, Merethe; Seternes, Ole Morten; Bang, Berit. Proteases in Seafood as activators of inflammatory reactions in airway epithelial cells. Organic Dust Tromsø Symposium 2011-04-11 - 2011-04-13 2011.

  • Johansen, Steinar Daae; Andreassen, morten; Babiak, Igor; Bizuayehu, Teshome; Coucheron, Dag-Hugo; El-Gewely, M. Raafat; Emblem, Åse; Fiskaa, Tonje; Furmanek, Tomasz; Haugli, kari b.; Karlsen, Bård Ove; Klingan, Kevin; Knutsen, Erik; Jørgensen, Tor Erik; Moum, Truls Borg; Nordeide, Jarle Tryti; Okkenhaug, Siri; Rekvig, Ole Petter; Seternes, ole morten; Ursvik, anita. Investigating miRNAs and transcriptomes at our local SOLiD sequencing facility. The Norwegian Biochemical Society 47th Contact Meeting 2011-02-03 - 2011-02-06 2011.

  • Larsen, Anett Kristin; Bang, Berit; Seternes, Ole Morten. Proteases from seafood as activators of protease-activated receptor-2 in airway epithelial cells. 2010 ISBN 978-82-7589-284-1.

  • Larsen, Merethe; Bang, Berit; Seternes, ole morten; Larsen, Anett K.. Protease-activated signal pathways in airway cells. Purified salmon trypsin activates nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549). Allergy. European Journal of Allergy and Clinical Immunology 2007; Volum 62. ISSN 0105-4538.

  • Larsen, Anett Kristin; Larsen, Merethe; Seternes, Ole Morten; Bang, Berit. Protease-activated signal pathways in airway cells. Purified salmon trypsin activates Nuclear factor kappa-B and induces interleukin-8 secretion in human airway epithelial cells (A549). XXVI Congress of the European Academy of Allergology and Clinical Immunology 2007-06-21 - 2007-06-23 2007.

  • Åberg, Espen; Perander, maria; Johansen, Bjarne Herold; Julien, Catherine; Meloche, Sylvain; Keyse, Stephen M; Seternes, ole morten. Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAP kinase ERK4/MAPK4. 15th Protein Kinase Meeting 2006-09-21 - 2006-09-24 2006.

  • Seternes, ole morten. The atypical MAP kinases ERK3 and 4 defines novel signaling pathways. Instituttseminar 2006-11-07 - 2006.

  • Seternes, ole morten. The atypical MAP kinases ERK3 and 4 defines novel signaling pathways. Seminar 2006-11-10 - 2006.

  • Member of research group