Photo: INGAR LEIROS
Ingar Leiros
- Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar; Kirpekar, Finn; Klungland, Arne; Alsøe, Lene; Nilsen, Hilde; Bjelland, Svein. Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology 2021; Volum 12. ISSN 1664-3224.s doi: 10.3389/fimmu.2021.762032.
- Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar; Ruoff, Peter; Kvaløy, Jan Terje; Knævelsrud, Ingeborg; Ånensen, Hilde; Alexeeva, Marina; Sato, Kousuke; Matsuda, Akira; Alseth, Ingrun; Klungland, Arne; Bjelland, Svein. The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside. Frontiers in Microbiology 2020; Volum 11. ISSN 1664-302X.s doi: 10.3389/fmicb.2020.00263.
- Hillier, Heidi Therese; Altermark, Bjørn; Leiros, Ingar. The crystal structure of the tetrameric DABA-aminotransferase EctB, a rate-limiting enzyme in the ectoine biosynthesis pathway.. The FEBS Journal 2020; Volum 287. ISSN 1742-464X.s 4641 - 4641.s doi: 10.1111/febs.15265.
- Berg, Kristel; Pedersen, Hege Lynum; Leiros, Ingar. Biochemical characterization of ferric uptake regulator (Fur) from Aliivibrio salmonicida. Mapping the DNA sequence specificity through binding studies and structural modelling. Biometals 2020; Volum 33. ISSN 0966-0844.s 169 - 185.s doi: 10.1007/s10534-020-00240-6.
- Berg, Kristel; Leiros, Ingar; Williamson, Adele Kim. Temperature adaptation of DNA ligases from psychrophilic organisms. Extremophiles 2019; Volum 23 (3). ISSN 1431-0651.s 305 - 317.s doi: 10.1007/s00792-019-01082-y.
- Piotrowski, Yvonne; Berg, Kristel; Klebl, David P.; Leiros, Ingar; Larsen, Atle Noralf. Characterization of an intertidal zone metagenome oligoribonuclease and the role of the intermolecular disulfide bond for homodimer formation and nuclease activity. FEBS Open Bio 2019; Volum 9 (10). ISSN 2211-5463.s 1674 - 1688.s doi: 10.1002/2211-5463.12720.
- Grgic, Miriam; Williamson, Adele Kim; Bjerga, Gro Elin Kjæreng; Altermark, Bjørn; Leiros, Ingar. Biochemical characterization of ParI, an orphan C5-DNA methyltransferase from Psychrobacter arcticus 273-4. Protein Expression and Purification 2018; Volum 150. ISSN 1046-5928.s 100 - 108.s doi: 10.1016/j.pep.2018.05.012.
- Jensen, Marianne Slang; Fredriksen, Lasse; Mackenzie, Alasdair; Pope, Phillip; Leiros, Ingar; Chylenski, Piotr; Williamson, Adele Kim; Christopeit, Tony; Østby, Heidi; Vaaje-Kolstad, Gustav; Eijsink, Vincent. Discovery and characterization of a thermostable two-domain GH6 endoglucanase from a compost metagenome. PLOS ONE 2018; Volum 13 (5). ISSN 1932-6203.s doi: 10.1371/journal.pone.0197862.
- Bjerga, Gro Elin Kjæreng; Larsen, Øivind; ARSIN, Hasan; Williamson, Adele Kim; Garcia-Moyano, Antonio; Leiros, Ingar; Puntervoll, Pål. Mutational analysis of the pro-peptide of a marine intracellular subtilisin protease supports its role in inhibition. Proteins: Structure, Function, and Bioinformatics 2018. ISSN 0887-3585.s 1 - 13.s doi: 10.1002/prot.25528.
- Kristiansen, Anders; Grgic, Miriam; Altermark, Bjørn; Leiros, Ingar. Properties and distribution of a metallo-β-lactamase (ALI-1) from the fish pathogen Aliivibrio salmonicida LFI1238. Journal of Antimicrobial Chemotherapy 2015; Volum 70 (3). ISSN 0305-7453.s 766 - 772.s doi: 10.1093/jac/dku433.
- Pedersen, Hege Lynum; Johnson, Kenneth; McVey, Colin; Leiros, Ingar; Moe, Elin. Structure determination of uracil-DNA N-glycosylase from Deinococcus radiodurans in complex with DNA. Acta Crystallographica Section D: Biological Crystallography 2015; Volum 71. ISSN 0907-4449.s 2137 - 2149.s doi: 10.1107/S1399004715014157.
- Moe, Elin; Assefa, Netsanet Gizaw; Leiros, Ingar; Torseth, Kathrin; Smalås, Arne O.; Willassen, Nils Peder. Reduced Hydrophobicity of the Minor Groove Intercalation Loop is Critical for Efficient Catalysis by Cold Adapted Uracil-DNA N-Glycosylase from Atlantic Cod. Journal of Thermodynamics & Catalysis 2015; Volum 6 (3). ISSN 2157-7544.s doi: 10.4172/2157-7544.1000155.
- Leiros, Hanna-Kirsti S.; Skagseth, Susann; Edvardsen, Kine Susann Waade; Lorentzen, Marit Sjo; Bjerga, Gro Elin Kjæreng; Leiros, Ingar; Samuelsen, Ørjan. His224 alters the R2 drug binding site and Phe218 influences the catalytic efficiency of the metallo-β-lactamase VIM-7. Antimicrobial Agents and Chemotherapy 2014; Volum 58 (8). ISSN 0066-4804.s 4826 - 4836.s doi: 10.1128/AAC.02735-13.
- Moe, Elin; Hall, D R; Leiros, Ingar; Monsen, Vivi Talstad; Timmins, Joanna; McSweeney, Sean. Structure-function studies of an unusual 3-methyladenine DNA glycosylase II (AlkA) from Deinococcus radiodurans. Acta Crystallographica Section D: Biological Crystallography 2012; Volum 68. ISSN 0907-4449.s 703 - 712.s doi: 10.1107/S090744491200947X.
- Leiros, Hanna-Kirsti S.; Fedøy, Anita-Elin; Leiros, Ingar; Steen, Ida Helene. The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila support a new active site locking mechanism. FEBS Open Bio 2012. ISSN 2211-5463.s doi: 10.1016/j.fob.2012.06.003.
- Saradhi, Pardha; Leiros, Hanna-Kirsti S.; Ahmad, Rafi; Spencer, James; Leiros, Ingar; Walsh, Timothy R.; Sundsfjord, Arnfinn; Samuelsen, Ørjan. Structural and Computational Investigations of VIM-7: Insights into the Substrate Specificity of VIM Metallo-beta-Lactamases. Journal of Molecular Biology (JMB) 2011; Volum 411 (1). ISSN 0022-2836.s 174 - 189.s doi: 10.1016/j.jmb.2011.05.035.
- Knævelsrud, Ingeborg; Moen, Marivi; Grøsvik, Kristin; Haugland, Gyri Teien; Birkeland, Nils-Kåre; Klungland, Arne; Leiros, Ingar; Bjelland, Svein. The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement. Journal of Bacteriology 2010; Volum 192 (21). ISSN 0021-9193.s 5755 - 5766.s doi: 10.1128/JB.00135-10.
- Pedersen, hege lynum; Ahmad, Rafi; Riise, EK; Leiros, Hanna-Kirsti S.; Hauglid, Stefan; Espelid, S; Brandsdal, Bjørn Olav; Leiros, Ingar; Willassen, Nils P; Haugen, Peik. Experimental and computational characterization of the ferric uptake regulator from Aliivibrio salmonicida (Vibrio salmonicida). Journal of Microbiology 2010; Volum 48 (2). ISSN 1225-8873.s 174 - 183.s doi: 10.1007/s12275-010-9199-5.
- Ræder, Inger Lin Uttakleiv; Moe, Elin; Willassen, Nils Peder; Smalås, Arne Oskar; Leiros, Ingar. Structure of uracil-DNA N-glycosylase (UNG) from Vibrio cholerae: mapping temperature adaptation through structural and mutational analysis. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2010; Volum 66. ISSN 1744-3091.s 130 - 136.s doi: 10.1107/S1744309109052063.
- Byeon, In-Ja L.; Dao, Khanh Kim; Jung, Jinwon; Keen, Thomas Jeffrey; Leiros, Ingar; Doskeland, Stein Ove; Martinez, Aurora; Gronenborn, Angela M.. Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMR. Journal of Biological Chemistry 2010; Volum 285 (18). ISSN 0021-9258.s 14062 - 14070.s doi: 10.1074/jbc.M110.106666.
- Knaevelsrud, I; Knaevelsrud, I; Slupphaug, G; Leiros, Ingar; Matsuda, A; Ruoff, P; Ruoff, P; Bjelland, S; Bjelland, S. Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. International Journal of Radiation Biology 2009; Volum 85 (5). ISSN 0955-3002.s 413 - 420.s doi: 10.1080/09553000902818915.
- Pedersen, hege lynum; Willassen, Nils Peder; Leiros, Ingar. The first structure of a cold-adapted superoxide dismutase (SOD): biochemical and structural characterization of iron SOD from Aliivibrio salmonicida. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2009; Volum 65. ISSN 1744-3091.s 84 - 92.s doi: 10.1107/S1744309109001110.
- Robertson, AB; Klungland, A; Rognes, T; Leiros, Ingar. DNA Repair in Mammalian Cells. Cellular and Molecular Life Sciences (CMLS) 2009; Volum 66 (6). ISSN 1420-682X.s 981 - 993.s doi: 10.1007/s00018-009-8736-z.
- Knævelsrud, I.; Slupphaug, Geir; Leiros, Ingar; Matsuda, A.; Ruoff, Peter; Bjelland, Svein. Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1. (omtale) International Journal of Radiation Biology 2009; Volum 85 (5). ISSN 0955-3002.s 413 - 420.
- Kapp, U.; Macedo, S.; Hall, David Richard; Leiros, Ingar; McSweeney, Sean; mitchell, edward. Structure of Deinococcus radiodurans tunicamycin-resistance protein (TmrD), a phosphotransferase. Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2008; Volum 64 (6). ISSN 1744-3091.s 479 - 486.
- Ræder, Inger Lin Uttakleiv; Leiros, Ingar; Willassen, Nils Peder; Smalås, Arne Oskar; Moe, Elin. Uracil-DNA N-glycosylase (UNG) from the marine, psychrophilic bacterium Vibrio salmonicida shows cold adapted features A comparative analysis to Vibrio cholerae uracil-DNA N-glycosylase. Enzyme and Microbial Technology 2008; Volum 42 (7). ISSN 0141-0229.s 594 - 600.s doi: 10.1016/j.enzmictec.2008.02.005.
- Leiros, Ingar; Nabong, Marivi P.; Grøsvik, Kristin; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Reite, Karen; Olsbu, Inger K.; Knævelsrud, I.; Moe, Elin; Andersen, Ole A.; Birkeland, Nils-Kåre; Ruoff, Peter; Klungland, Arne; Bjelland, Svein. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal 2007; Volum 26. ISSN 0261-4189.
- Stokke, R; Leiros, Ingar; Karlström, Mikael; Karlstrom, M; Yang, Nannan; Ladenstein, R; Birkeland, NK; Steen, IH. Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers. Extremophiles 2007; Volum 11. ISSN 1431-0651.s doi: 10.1007/s00792-006-0060-z.
- Leiros, Hanna-Kirsti S.; Pey, AL; Innselset, M; Innselset, Marte; Moe, Elin; Leiros, Ingar; Steen, IH; Martinez, A. Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability. Journal of Biological Chemistry 2007; Volum 282. ISSN 0021-9258.s doi: 10.1074/jbc.M610174200.
- Leiros, Ingar; Nabong, Marivi; Nabong, MP; Grosvik, K; Grøsvik, Kristin; Ringvoll, J; Ringvoll, Jeanette; Haugland, GT; Uldal, Lene; Uldal, L; Reite, K; Olsbu, IK; Knævelsrud, Ingeborg; Knaevelsrud, I; Moe, Elin; Andersen, Ole Andreas; Birkeland, NK; Ruoff, P; Klungland, A; Bjelland, S. Structural basis for enzymatic excision of N-1-methyladenine and N-3-methylcytosine from DNA. EMBO Journal 2007; Volum 26. ISSN 0261-4189.s doi: 10.1038/sj.emboj.7601662.
- Timmins, J; Leiros, Ingar; McSweeney, S. Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding. EMBO Journal 2007; Volum 26. ISSN 0261-4189.s 3260 - 3271.s doi: 10.1038/sj.emboj.7601760.
- Leiros, Ingar; Wang, Ellen; Rasmussen, Tonni; Oksanen, Esko; Repo, Heidi; Petersen, S. B.; Heikinheimo, Pirkko; Hough, Edward. The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX). Acta Crystallographica. Section F : Structural Biology and Crystallization Communications 2006; Volum 62 (12). ISSN 1744-3091.s 1185 - 1190.
- Sørmo, Christopher; Leiros, Ingar; Brembu, T.; Winge, Per; Os, vibeke; Bones, Atle M. The crystal structure of Arabidopsis thaliana RAC7/ROP9: The first RAS superfamily GTPase from the plant kingdom. Phytochemistry 2006; Volum 67 (21). ISSN 0031-9422.s 2332 - 2340.
- Moe, Elin; Leiros, Ingar; Smalås, Arne Oskar; McSweeney, Sean. The crystal structure of mismatch-specific uracil-DNA glycosylase (MUG) from Deinococcus radiodurans reveals a novel catalytic residue and broad substrate specificity. Journal of Biological Chemistry 2006; Volum 281. ISSN 0021-9258.
- Leiros, Ingar; Moe, Elin; Smalås, Arne Oskar; McSweeney, Sean. Structure of the uracil-DNA N-glycosylase (UNG) from Deinococcus radiodurans. Acta Crystallographica Section D: Biological Crystallography 2005; Volum 61. ISSN 0907-4449.
- Timmins, Joanna; Leiros, Hanna-Kirsti S.; Leonard, Gordon; Leiros, Ingar; McSweeney, Sean. Crystal structure of maltooligosyltrehalose trehalohydrolase from Deinococcus radiodurans in complex with disaccharides. Journal of Molecular Biology (JMB) 2005; Volum 347 (5). ISSN 0022-2836.s 949 - 963.
- Johnsen, Line; Dalhus, Bjørn; Leiros, Ingar; Nissen-meyer, Jon. 1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferring immunity to the antimicrobial activity of the pediocin-like bacteriocin enterocin A. Journal of Biological Chemistry 2005; Volum 280 (19). ISSN 0021-9258.s 19045 - 19050.
- Leiros, Ingar; Timmins, Joanna; Hall, David Richard; McSweeney, Sean. Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans. EMBO Journal 2005; Volum 24 (5). ISSN 0261-4189.s 906 - 918.
- Moe, Elin; Leiros, Ingar; Riise, Ellen Kristin; Olufsen, Magne; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua). Journal of Molecular Biology (JMB) 2004; Volum 343 (5). ISSN 0022-2836.s 1221 - 1230.
- Leiros, Hanna-Kirsti S.; Leiros, Hanna Kirsti Schrøder; Brandsdal, Bjørn Olav; Andersen, Ole Andreas; Os, vibeke; Leiros, Ingar; Leiros, Ingar; Helland, Ronny; Otlewski, J.; Otlewski, Jacek; Willassen, Nils Peder; Smalås, Arne Oskar. Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements. Protein Science 2004; Volum 13. ISSN 0961-8368.s 1056 - 1070.
- Leiros, Ingar; Leiros, Ingar; McSweeney, S.; McSweeney, Sean; Hough, Edward. The reaction mechanism of phospholipase D from Streptomyces sp strain PMF. snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. Journal of Molecular Biology (JMB) 2004; Volum 339. ISSN 0022-2836.s 805 - 820.
- Stenvik, jØrgen; Solstad, therese; Strand, cato; Leiros, Ingar; Jørgensen, Trond Ø.. Cloning and analyses of a BPI/LBP cDNA of the Atlantic cod (Gadus morhua L.). Developmental and Comparative Immunology 2004; Volum 28. ISSN 0145-305X.s 307 - 323.
- Helland, Ronny; Czapinska, Honorata; Leiros, Ingar; Olufsen, Magne; Otlewski, Jacek; Smalås, Arne Oskar. Structural Consequences of Accommodation of Four Non-cognate Amino Acid Residues in the S1 Pocket of Bovine Trypsin and Chymotrypsin. Journal of Molecular Biology (JMB) 2003; Volum 333 (4). ISSN 0022-2836.s 845 - 861.
- Leiros, Ingar; Moe, Elin; Lanes, Olav; Smalås, Arne Oskar; Willassen, Nils Peder. The crystal structure of uracil-DNA-glycosylase from Atlantic cod (Gadus morhua) reveals cold-adaptation fetures. Acta Crystallographica Section D: Biological Crystallography 2003; Volum 59. ISSN 0907-4449.s 1357 - 1365.
- Heikinheimo, Pirkko a; Helland, Ronny; Leiros, Hanna-Kirsti S.; Leiros, Ingar; Karlsen, Solveig; Evjen, gry; Ravelli, Raimond; Schoehn, Guy; Ruigrok, Rob; McSweeney, Sean; Hough, Edward. The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation. Journal of Molecular Biology (JMB) 2003; Volum 327 (3). ISSN 0022-2836.s 631 - 644.
- Lanes, Olav; Leiros, Ingar; Smalås, Arne Oskar; Willassen, Nils Peder. Identification, cloning, and expression of uracil-DNA glycosylase from Atlantic cod (gadus morhua): charcterization and homology modeling of the cold-active catalytic domain. Extremophiles 2002; Volum 6. ISSN 1431-0651.s 73 - 86.
- Bossi, L.; D'Arrigo, P.; Pedrocchi-Fantoni, G.; Mele, A.; Servi, S.; Leiros, Ingar. The substrate requirements of phospholipase D. Journal of Molecular Catalysis B: Enzymatic 2001; Volum 11. ISSN 1381-1177.s 433 - 438.
- Leiros, Ingar; Lanes, Olav; Sundheim, Ottar; Helland, Ronny; Smalås, Arne O; Willassen, Nils P. Crystallization and preliminary X-ray diffraction analysis of a cold-adapted uracil-DNA glycosylase from Atlantic cod (Gadus morhua). Acta Crystallographica Section D: Biological Crystallography 2001; Volum 57 (11). ISSN 0907-4449.s 1706 - 1708.s doi: 10.1107/S0907444901013427.
- Leiros, Ingar; Lanes, Olav; Sundheim, Ottar; Helland, Ronny; Smalås, Arne Oskar; Willassen, Nils Peder. Crystallization and preliminary X-ray diffraction analysis of a cold-adapted uracil-DNA glycosylase from Atlantic cod (Gadus morhua). Acta Crystallographica Section D: Biological Crystallography 2001; Volum 57. ISSN 0907-4449.s 1706 - 1708.
- Leiros, Ingar; Secundo, F.; Cambonelli, Carlo; Servi, S.; Hough, Edward. The first crystal structure of a phospholipase D. Structure 2000; Volum 8. ISSN 0969-2126.s 655 - 667.
- Leiros, Ingar; Hough, Edward; D'Arrigo, P.; Carrea, G.; Pedrocchi-Fantoni, G.; Secundo, F.; Servi, S.. Crystallization and preliminary X-ray diffraction studies of Phospholipase D from Streptomyces sp. Acta Crystallographica Section D: Biological Crystallography 2000; Volum 56. ISSN 0907-4449.s 466 - 468.
- Helland, Ronny; Leiros, Ingar; Berglund, Gunnar Inge; Willassen, Nils Peder; Smalås, Arne Oskar. The crystal structure of anionic salmon trypsin in complex with bovine pancreatic trypsin inhibitor. European Journal of Biochemistry (EJB) 1998; Volum 256 (2). ISSN 0014-2956.s 317 - 324.